H
Hella Kohlhof
Publications - 5
Citations - 114
Hella Kohlhof is an academic researcher. The author has contributed to research in topics: Dihydroorotate dehydrogenase & Acetylation. The author has an hindex of 4, co-authored 5 publications receiving 68 citations.
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Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
Wolfgang Gruber,Elisabeth Peer,Dominik P. Elmer,Christina Sternberg,Suzana Tesanovic,Pedro J Del Burgo,Sonia Coni,Gianluca Canettieri,Daniel Neureiter,René Bartz,Hella Kohlhof,Daniel Vitt,Fritz Aberger +12 more
TL;DR: It is proposed that the inhibition of HDACs 1/2/3 is crucial for targeting oncogenic HH/GLI signaling, and that class I HDAC inhibitors either in combination with SMOi or as second‐line therapy may improve the treatment options for HH‐associated malignancies withSMOi resistance.
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IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
Friedrich Hahn,Christina Wangen,Sigrun Häge,Antonia Sophia Peter,Gerhard Dobler,Brett L. Hurst,Justin G. Julander,Jonas Fuchs,Zsolt Ruzsics,Klaus Überla,Hans-Martin Jäck,Roger G. Ptak,Andreas Muehler,Manfred Gröppel,Daniel Vitt,Evelyn Peelen,Hella Kohlhof,Manfred Marschall +17 more
TL;DR: Vidofludimus, the active determinant of IMU-838, exerted a broad-spectrum activity against a selection of major human pathogenic viruses, suggesting that developmental DHODH inhibitors represent promising candidates for use as anti-SARS-CoV-2 therapeutics.
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Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells
Marion Wobser,Alexandra Weber,Amelie Glunz,Saskia Tauch,Kristina Seitz,Tobias Butelmann,Sonja Hesbacher,Matthias Goebeler,René Bartz,Hella Kohlhof,David Schrama,Roland Houben +11 more
TL;DR: It is demonstrated that 4SC-202, a drug currently tested in clinical trials, effectively inhibits growth of CTCL cells and is also a potent microtubule-destabilizing agent.
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Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro
Yu-Jin Kim,Beatrice Cubitt,Yíngyún Caì,Jens H. Kuhn,Daniel Vitt,Hella Kohlhof,Juan Carlos de la Torre +6 more
TL;DR: Five novel DHODH inhibitors evaluated resulted in a potent interferon-independent inhibition of mammarenavirus multiplication in vitro, including the highly virulent Lassa and Junín viruses.
Journal ArticleDOI
Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2.
Friedrich Hahn,Sigrun Häge,Alexandra Herrmann,Christina Wangen,Jintawee Kicuntod,Doris Jungnickl,Julia Tillmanns,Regina Müller,Kirsten Fraedrich,Klaus Überla,Hella Kohlhof,Armin Ensser,Manfred Marschall +12 more
TL;DR: In this article, a multi-readout assay (MRA) system was proposed for the assessment and mechanistic characterization of novel test compounds, drug repurposing and combination treatments of SARS-CoV-2.