Mark W. H. Hoorens

TL;DR: This work describes the applications scenarios that can be envisioned in clinical practice and uses those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology.

TL;DR: In this article, the authors describe selected developments in photopharmacology that aim at establishing such control over protein activity through bioactive molecules with photo-controlled potency, and discuss why such control is desired and what challenges still need to be overcome for photopharma to reach its maturity as a chemical biology research tool.

TL;DR: Iminothioindoxyls are reported as visible-light operated photoswitches with a band separation of 100 nm, which paves the way for the development of improved photo-controlled systems for a wide variety of applications that require fast responsive functions.

TL;DR: The development of BRAFV600E kinase inhibitors of which the activity can be switched on and off reversibly with light is shown, offering the possibility to overcome problems of systemic drug activity by selectively activating the drug at the desired site of action.

TL;DR: In this article, the authors summarized the current knowledge of the functional heterogeneity and biology of CAFs in cancer and highlighted the latest developments towards theranostic applications that will help tumour characterization, radioligand therapy and staging in cancers with a distinct CAF population.