H
Heng Zhang
Researcher at Central South University
Publications - 16
Citations - 824
Heng Zhang is an academic researcher from Central South University. The author has contributed to research in topics: Phosphorylation & Autophagy. The author has an hindex of 9, co-authored 12 publications receiving 461 citations. Previous affiliations of Heng Zhang include China Three Gorges University.
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Journal ArticleDOI
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
Huiwen Song,Xing Feng,Heng Zhang,Yunmei Luo,Juan Huang,Meihua Lin,Junfei Jin,Xue Ding,Shujing Wu,He Huang,Tian Yu,Mukun Zhang,Haiou Hong,Shihua Yao,Yongxiang Zhao,Zhiyong Zhang +15 more
TL;DR: A critical link between METTL3-ALKBH5 and autophagy is uncovered, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease.
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Reciprocal activation between ATPase inhibitory factor 1 and NF‐κB drives hepatocellular carcinoma angiogenesis and metastasis
Ruipeng Song,Huiwen Song,Yingjian Liang,Dalong Yin,Heng Zhang,Tongsen Zheng,Jiabei Wang,Zhaoyang Lu,Xuan Song,Tiemin Pei,Youyou Qin,Yuejin Li,Changming Xie,Boshi Sun,Huawen Shi,Shuai Li,Xianzhi Meng,Guangchao Yang,Shangha Pan,Jiyuan Zhu,Shu-Yi Qi,Hongchi Jiang,Zhiyong Zhang,Lianxin Liu +23 more
TL;DR: It is found that increased expression of IF1 in human HCC predicts poor survival and disease recurrence after surgery, and the combination of these two parameters was a more powerful predictor of poor prognosis.
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Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation.
Chao Qu,De He,Xiaoling Lu,Lihua Dong,Yuekun Zhu,Qin Zhao,Jiang Xin,Pengyu Chang,Xinping Jiang,Lizhe Wang,Yuyu Zhang,Lirong Bi,Jian He,Yi Peng,Jing Su,Heng Zhang,He Huang,Yan Li,Sufang Zhou,Yaqin Qu,Yongxiang Zhao,Zhiyong Zhang,Zhiyong Zhang +22 more
TL;DR: The findings highlight the critical roles of SIK1 and its targets in the regulation of HCC development and provides potential new candidates for HCC therapy.
Journal ArticleDOI
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5
Xing Feng,Xing Feng,Heng Zhang,Lingbing Meng,Huiwen Song,Qingxin Zhou,Qingxin Zhou,Chao Qu,Pan Zhao,Pan Zhao,Qinghua Li,Chang Zou,Chang Zou,Xing Liu,Zhiyong Zhang,Zhiyong Zhang +15 more
TL;DR: It is reported that PAK1 (p21 [RAC1] activated kinase 1) is significantly upregulated and promotes GBM development and its regulator in the autophagy pathway might represent potential therapeutic targets for GBM treatment.
Journal ArticleDOI
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth
Xing Feng,Yanyan Jia,Yuyu Zhang,Fei Ma,Yuekun Zhu,Xuehui Hong,Qingxin Zhou,Ruixing He,Heng Zhang,Junfei Jin,Daxun Piao,He Huang,Qinghua Li,Xingfeng Qiu,Zhiyong Zhang +14 more
TL;DR: In vitro and in vivo evidence is provided that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth.