H
Huiwen Song
Researcher at University of Medicine and Health Sciences
Publications - 11
Citations - 668
Huiwen Song is an academic researcher from University of Medicine and Health Sciences. The author has contributed to research in topics: Autophagy & Phosphorylation. The author has an hindex of 7, co-authored 9 publications receiving 405 citations. Previous affiliations of Huiwen Song include Southern Medical University & Zunyi Medical College.
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Journal ArticleDOI
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
Huiwen Song,Xing Feng,Heng Zhang,Yunmei Luo,Juan Huang,Meihua Lin,Junfei Jin,Xue Ding,Shujing Wu,He Huang,Tian Yu,Mukun Zhang,Haiou Hong,Shihua Yao,Yongxiang Zhao,Zhiyong Zhang +15 more
TL;DR: A critical link between METTL3-ALKBH5 and autophagy is uncovered, providing insight into the functional importance of the reversible mRNA m6A methylation and its modulators in ischemic heart disease.
Journal ArticleDOI
Reciprocal activation between ATPase inhibitory factor 1 and NF‐κB drives hepatocellular carcinoma angiogenesis and metastasis
Ruipeng Song,Huiwen Song,Yingjian Liang,Dalong Yin,Heng Zhang,Tongsen Zheng,Jiabei Wang,Zhaoyang Lu,Xuan Song,Tiemin Pei,Youyou Qin,Yuejin Li,Changming Xie,Boshi Sun,Huawen Shi,Shuai Li,Xianzhi Meng,Guangchao Yang,Shangha Pan,Jiyuan Zhu,Shu-Yi Qi,Hongchi Jiang,Zhiyong Zhang,Lianxin Liu +23 more
TL;DR: It is found that increased expression of IF1 in human HCC predicts poor survival and disease recurrence after surgery, and the combination of these two parameters was a more powerful predictor of poor prognosis.
Journal ArticleDOI
PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
Xuehui Hong,Ruipeng Song,Huiwen Song,Tongsen Zheng,Jiabei Wang,Yingjian Liang,Shu-Yi Qi,Zhaoyang Lu,Xuan Song,Hongchi Jiang,Lianxin Liu,Zhiyong Zhang +11 more
TL;DR: The results establish the counteraction between PTEN and Tcl1 as a key mechanism that regulates the PPP and suggest that targeting the PTEN/Tcl1/hnRNPK/G6PD axis could open up possibilities for therapeutic intervention and improve the prognosis of patients with HCC.
Journal ArticleDOI
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5
Xing Feng,Xing Feng,Heng Zhang,Lingbing Meng,Huiwen Song,Qingxin Zhou,Qingxin Zhou,Chao Qu,Pan Zhao,Pan Zhao,Qinghua Li,Chang Zou,Chang Zou,Xing Liu,Zhiyong Zhang,Zhiyong Zhang +15 more
TL;DR: It is reported that PAK1 (p21 [RAC1] activated kinase 1) is significantly upregulated and promotes GBM development and its regulator in the autophagy pathway might represent potential therapeutic targets for GBM treatment.
Journal ArticleDOI
ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
Huiwen Song,Jun Pu,Lin Wang,Lihua Wu,Jianmin Xiao,Qigong Liu,Jun Chen,Min Zhang,Yang Liu,Mingke Ni,Jinggang Mo,Yunliang Zheng,Deli Wan,XiongJiu Cai,Yaping Cao,Weiyi Xiao,Lei Ye,Enyuan Tu,Zhihai Lin,Jianxin Wen,Xiaoling Lu,Jian He,Yi Peng,Jing Su,Heng Zhang,Yongxiang Zhao,Meihua Lin,Zhiyong Zhang +27 more
TL;DR: ATG16L1 is identified as a bona fide physiologicalCSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12-ATG5-ATg16L 1 complex and autophagic induction.