H
Hengyuan Zhang
Researcher at China Pharmaceutical University
Publications - 15
Citations - 315
Hengyuan Zhang is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Antibacterial activity & HeLa. The author has an hindex of 10, co-authored 15 publications receiving 245 citations.
Papers
More filters
Journal ArticleDOI
Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates
Jie Liu,Qin Liu,Xue Yang,Shengtao Xu,Hengyuan Zhang,Renren Bai,Hequan Yao,Jieyun Jiang,Mingqin Shen,Xiaoming Wu,Jinyi Xu +10 more
TL;DR: Biological evaluation in vivo suggested that 14f is obviously superior to that of reference drug losartan in RHRs, and meanwhile, 14f has no significant impact on heart rate.
Journal ArticleDOI
Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents
Yun-Kai Zhang,Hengyuan Zhang,Guan-Nan Zhang,Yi-Jun Wang,Rishil J. Kathawala,Rui Si,Bhargav A. Patel,Jinyi Xu,Zhe-Sheng Chen +8 more
TL;DR: It is concluded that ORA reverseABCB1-mediated MDR by competitively inhibiting the ABCB1 drug efflux function by reverse the resistance to paclitaxel and vincristine in ABCB 1-overexpressing SW620/Ad300 and HEK/ABCB 1 cells.
Journal ArticleDOI
Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents.
Zhou Zhiwen,Cong Ma,Hengyuan Zhang,Yi Bi,Chen Xia,Hua Tian,Xiaoni Xie,Qing-Guo Meng,Peter J. Lewis,Jinyi Xu +9 more
TL;DR: A novel class of ocotillol-type triterpenoid derivatives have been synthesized and evaluated for their in-vitro antibacterial activity against several representative pathogenic bacterial strains.
Journal ArticleDOI
Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation.
Dahong Li,Shengtao Xu,Hao Cai,Lingling Pei,Hengyuan Zhang,Lei Wang,Hequan Yao,Xiaoming Wu,Jieyun Jiang,Yijun Sun,Jinyi Xu +10 more
TL;DR: Mechanistic investigation showed that the representative compound 17 affected cell cycle and induced apoptosis at low micro-molar level in human hepatoma Bel-7402 cells, via an oxidative stress triggered mitochondria-related caspase-dependent pathway.
Journal ArticleDOI
Design, synthesis and antitumor activity of triterpenoid pyrazine derivatives from 23-hydroxybetulinic acid.
Hengyuan Zhang,Wang Yiwei,Peiqing Zhu,Jie Liu,Shengtao Xu,Hequan Yao,Jieyun Jiang,Wen-Cai Ye,Xiaoming Wu,Jinyi Xu +9 more
TL;DR: The biological screening results showed that all of the derivatives exhibited more significant antiproliferative activity than the parent compound and pyrazine-fused 23-hydroxybetulinic acid exhibited the most potent activity.