H
Henning Seedorf
Researcher at Temasek Life Sciences Laboratory
Publications - 42
Citations - 6868
Henning Seedorf is an academic researcher from Temasek Life Sciences Laboratory. The author has contributed to research in topics: Microbiome & Genome. The author has an hindex of 18, co-authored 38 publications receiving 5719 citations. Previous affiliations of Henning Seedorf include Washington University in St. Louis & Max Planck Society.
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Journal ArticleDOI
The Long-Term Stability of the Human Gut Microbiota
Jeremiah J. Faith,Janaki L. Guruge,Mark R. Charbonneau,Sathish Subramanian,Henning Seedorf,Andrew L. Goodman,Jose C. Clemente,Rob Knight,Rob Knight,Andrew C. Heath,Rudolph L. Leibel,Michael Rosenbaum,Jeffrey I. Gordon +12 more
TL;DR: Low-error sequencing data suggest that initial microbial colonizers of infant guts could persist over the life span of an individual, and members of Bacteroidetes and Actinobacteria are significantly more stable components than the population average.
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Methanogenic archaea: ecologically relevant differences in energy conservation.
TL;DR: In methanogens with cytochromes, the first and last steps in methanogenesis from CO2 are coupled chemiosmotically, whereas in methenogens without cyto Chromes, these steps are energetically coupled by a cytoplasmic enzyme complex that mediates flavin-based electron bifurcation.
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Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Michael A. Mahowald,Federico E. Rey,Henning Seedorf,Peter J. Turnbaugh,Robert S. Fulton,Aye Wollam,Neha Shah,Chunyan Wang,Vincent Magrini,Richard K. Wilson,Brandi L. Cantarel,Brandi L. Cantarel,Pedro M. Coutinho,Bernard Henrissat,Bernard Henrissat,Lara W. Crock,Alison L Russell,Nathan C Verberkmoes,Robert L. Hettich,Jeffrey I. Gordon +19 more
TL;DR: A simplified model of the human gut microbiota illustrates niche specialization and functional redundancy within members of its major bacterial phyla, and the importance of host glycans as a nutrient foundation that ensures ecosystem stability.
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The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features
Henning Seedorf,W. Florian Fricke,Birgit Veith,Holger Brüggemann,Heiko Liesegang,Axel Strittmatter,Marcus Miethke,Wolfgang Buckel,Julia Hinderberger,Fu-Li Li,Christoph H. Hagemeier,Rudolf K. Thauer,Gerhard Gottschalk +12 more
TL;DR: The genome sequence of C. kluyveri was reported, which revealed new insights into the metabolic capabilities of this well studied organism and suggested that the two enzymes, which are isolated together in a macromolecular complex, form a carboxysome-like structure.
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Coupled Ferredoxin and Crotonyl Coenzyme A (CoA) Reduction with NADH Catalyzed by the Butyryl-CoA Dehydrogenase/Etf Complex from Clostridium kluyveri
TL;DR: Fredoxin reduction with NADH in cell extracts from Clostridium kluyveri is catalyzed by the butyryl-CoA dehydrogenase/Etf complex and the implications of this finding for the energy metabolism of butyrate-forming anaerobes are discussed in the accompanying paper.