H
Henry A. Erlich
Researcher at Hoffmann-La Roche
Publications - 87
Citations - 43463
Henry A. Erlich is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Human leukocyte antigen & Polymerase chain reaction. The author has an hindex of 46, co-authored 86 publications receiving 42600 citations. Previous affiliations of Henry A. Erlich include Children's Hospital Oakland Research Institute & Cetus Corporation.
Papers
More filters
Journal ArticleDOI
Recent advances in the polymerase chain reaction
TL;DR: Progresses ranging from the identification of novel genes and pathogens to the quantitation of characterized nucleotide sequences and some recent developments in instrumentation, methodology, and applications of the PCR are presented.
Journal ArticleDOI
Direct cloning and sequence analysis of enzymatically amplified genomic sequences
TL;DR: A method is described for directly cloning enzymatically amplified segments of genomic DNA into an M13 vector for sequence analysis and promises to be a rapid method for obtaining reliable genomic sequences from nanogram amounts of DNA.
Journal ArticleDOI
DNA typing from single hairs
TL;DR: Three different means of DNA typing are used for the determination of amplified DNA fragment length differences, hybridization with allele-specific oligonucleotide probes, and direct DNA sequencing on single human hairs to detect genetically variable mitochondrial and nuclear DNA sequences.
Journal ArticleDOI
Amplification and analysis of DNA sequences in single human sperm and diploid cells
Honghua Li,Ulf B. Gyllensten,Xiangfeng Cui,Randall Keichi Saiki,Henry A. Erlich,Norman Arnheim +5 more
TL;DR: The use of the polymerase chain reaction for analysing DNA sequences in individual diploid cells and human sperm shows that two genetic loci can be co-amplified from a single sperm, which may allow the analysis of previously inaccessible genetic phenomena.
Journal ArticleDOI
Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA
Corinne Wong,Carol E. Dowling,Randall Keichi Saiki,Russell Higuchi,Henry A. Erlich,Haig H. Kazazian +5 more
TL;DR: This work studied the genomic DNA of five patients with β-thalassaemia, and found two previously undescribed mutations, along with three known alleles, including the first natural mutation observed at the cap site of the β-globin gene.