H
Henry A. Erlich
Researcher at Hoffmann-La Roche
Publications - 87
Citations - 43463
Henry A. Erlich is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Human leukocyte antigen & Polymerase chain reaction. The author has an hindex of 46, co-authored 86 publications receiving 42600 citations. Previous affiliations of Henry A. Erlich include Children's Hospital Oakland Research Institute & Cetus Corporation.
Papers
More filters
Journal ArticleDOI
Implication of Specific DQB1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB1 Allele and Unusual DR2 and DR1 Haplotypes
Henry A. Erlich,Robert L Griffith,Teodorica L. Bugawan,Ralph Ziegler,Chester A. Alper,George S. Eisenbarth +5 more
TL;DR: Molecular analysis of the HLA class II genes in an unusual family with three HLA-DR1/2 siblings suggests that these unusual DQB1 alleles may confer susceptibility to IDDM in this family and, furthermore, that they may confer protection in the general population.
Journal ArticleDOI
HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.
Henry A. Erlich,Teodorica Bugawan,Stephen Joel Scharf,Gerald T. Nepom,Brian Tait,Robert L Griffith +5 more
TL;DR: The analysis of HLA-DQβ nucleotide sequence polymorphism in insulin-dependent diabetes mellitus (IDDM) patients and control subjects suggests a role for the DQβ-chain in genetic susceptibility as mentioned in this paper.
Journal ArticleDOI
HLA-DP typing by DNA amplification and hybridization with specific oligonucleotides.
Giovanna Angelini,Teodorica L. Bugawan,Laura Delfino,Henry A. Erlich,Giovanni Battista Ferrara +4 more
TL;DR: The oligonucleotide hybridization performed on DP omega-negative B-cell lines gave a pattern distinct from those of known DP omega specificities, indicating the presence of novel DP allelic sequences.
Journal ArticleDOI
Rapid detection and sequencing of alleles in the 3′ flanking region of the Interleukin-6 gene
TL;DR: The results illustrate the value of PCR for the rapid detection of length polymorphisms such as those due to variable numbers of tandem repeats, and take less than a day to perform, is cheaper, avoids the use of radioactivity and requires far less substrate DNA.
Journal ArticleDOI
A novel method for the detection of polymorphic restriction sites by cleavage of oligonucleotide probes: application to sickle-cell anemia
TL;DR: A simple and rapid method for the detection of specific polymorphic restriction sites has been developed that utilizes restriction endonuclease cleavage of a synthetic, end-labeled oligonucleotide probe annealed in solution to the target genomic DNA sequence.