H
Hermann Blankenbach
Researcher at University of Freiburg
Publications - 3
Citations - 180
Hermann Blankenbach is an academic researcher from University of Freiburg. The author has contributed to research in topics: Inflammation & Receptor. The author has an hindex of 3, co-authored 3 publications receiving 146 citations.
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Journal ArticleDOI
Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.
Dennis Wolf,Jan David Hohmann,Ansgar Wiedemann,Kamila Bledzka,Hermann Blankenbach,Timoteo Marchini,Katharina Gutte,Katharina Zeschky,Nicole Bassler,Natalie Hoppe,Alexandra Ortiz Rodriguez,Nadine Herr,Ingo Hilgendorf,Peter Stachon,Florian Willecke,Daniel Duerschmied,Constantin von zur Mühlen,Dmitry A. Soloviev,Li Zhang,Christoph Bode,Edward F. Plow,Peter Libby,Karlheinz Peter,Andreas Zirlik +23 more
TL;DR: The novel finding that CD40L binds to the EQLKKSKTL motif on Mac-1 mediating leukocyte recruitment and atherogenesis is presented, potentially avoiding the unwanted immunologic and thrombotic effects of global inhibition ofCD40L.
Journal ArticleDOI
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
Dennis Wolf,Dennis Wolf,Nathaly Anto-Michel,Hermann Blankenbach,Ansgar Wiedemann,Konrad Buscher,Jan David Hohmann,Bock Lim,Marina Bäuml,Alex Marki,Maximilian Mauler,Daniel Duerschmied,Zhichao Fan,Holger Winkels,Daniel Sidler,Philipp Diehl,Dirk M. Zajonc,Ingo Hilgendorf,Peter Stachon,Timoteo Marchini,Florian Willecke,Maximilian Schell,Maximilian Schell,Björn Sommer,Constantin von zur Mühlen,Jochen Reinöhl,Teresa Gerhardt,Edward F. Plow,Valentin P. Yakubenko,Peter Libby,Christoph Bode,Klaus Ley,Karlheinz Peter,Andreas Zirlik +33 more
TL;DR: An anti-Mac1 antibody is reported that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and it can protect against sepsis in mice and open a path for a new field of ligand-targeted anti-integrin therapy to prevent inflammatory conditions.
Journal ArticleDOI
Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO)
Dennis Wolf,Nora Bukosza,David Engel,Marjorie Poggi,Felix Jehle,Felix Jehle,Nathaly Anto Michel,Yung-Chih Chen,Christian Colberg,Natalie Hoppe,Bianca Dufner,Louis Boon,Hermann Blankenbach,Ingo Hilgendorf,Constantin von zur Mühlen,Jochen Reinöhl,Björn Sommer,Timoteo Marchini,Mark A. Febbraio,Christian Weber,Christoph Bode,Karlheinz Peter,Esther Lutgens,Andreas Zirlik +23 more
TL;DR: It is presented the surprising finding that adhesive properties of the leukocyte integrin Mac-1 are not required for macrophage accumulation in adipose tissue, Instead, Mac- 1 modulates inflammatory gene expression in macrophages, which questions the net effect of integrin blockade in cardio-metabolic disease.