H
Hervé Lerat
Researcher at University of Texas Medical Branch
Publications - 5
Citations - 656
Hervé Lerat is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Hepatitis C virus & Transgene. The author has an hindex of 5, co-authored 5 publications receiving 645 citations. Previous affiliations of Hervé Lerat include Centre national de la recherche scientifique & University of Montpellier.
Papers
More filters
Journal ArticleDOI
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.
Hervé Lerat,Masao Honda,Michael R. Beard,Kim Loesch,Jiaren Sun,Yan Yang,Michiari Okuda,Rainer Gosert,Shu-Yuan Xiao,Steven A. Weinman,Stanley M. Lemon +10 more
TL;DR: Constitutive expression of viral proteins leads to common pathologic features of hepatitis C in the absence of specific anti-viral immune responses, while additional low level expression of nonstructural proteins increases the risk of cancer.
Journal ArticleDOI
Impaired Clearance of Virus-Infected Hepatocytes in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein
Olivier Disson,Delphine Haouzi,Solange Desagher,Kim Loesch,Michael Hahne,Eric J. Kremer,Chantal Jacquet,Stanley M. Lemon,Urszula Hibner,Hervé Lerat +9 more
TL;DR: The results suggest that viral evasion of cell-mediated immune responses leading to apoptotic death of hepatocytes may contribute to viral persistence and might also contribute to the development of liver cancer in HCV.
Journal ArticleDOI
Cell Type-Specific Enhancement of Hepatitis C Virus Internal Ribosome Entry Site-Directed Translation due to 5′ Nontranslated Region Substitutions Selected during Passage of Virus in Lymphoblastoid Cells
TL;DR: The 2- to 2.5-fold increase in translation observed with the modified IRES sequence may facilitate the replication of HCV, possibly accounting for differences in quasispecies variants recovered from liver tissue and peripheral blood mononuclear cells of the same patient.
Journal ArticleDOI
Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway.
Yannick Simonin,Yannick Simonin,Olivier Disson,Olivier Disson,Hervé Lerat,Hervé Lerat,Etienne Antoine,Etienne Antoine,Fabien Binamé,Fabien Binamé,Arielle R. Rosenberg,Solange Desagher,Solange Desagher,Patrice Lassus,Patrice Lassus,Paulette Bioulac-Sage,Urszula Hibner,Urszula Hibner +17 more
TL;DR: Calpains activated by HCV proteins degrade Bid and thus dampen apoptotic signaling, suggesting that inhibiting calpains could lead to an improved efficiency of immune‐mediated elimination of HCV‐infected cells.
Journal Article
A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans.
TL;DR: Existing therapies for chronic hepatitis C include recombinant human interferon, either alone or in combination with ribavirin, which are only partially effective, leading to the belief that most if not all of the pathologic consequences of hepatitis C arise as a result of the cellular immune response to the infection.