P
Patrice Lassus
Researcher at University of Montpellier
Publications - 21
Citations - 1669
Patrice Lassus is an academic researcher from University of Montpellier. The author has contributed to research in topics: Apoptosis & Wild type. The author has an hindex of 16, co-authored 20 publications receiving 1594 citations. Previous affiliations of Patrice Lassus include French Institute of Health and Medical Research & Cold Spring Harbor Laboratory.
Papers
More filters
Journal ArticleDOI
Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization
TL;DR: It is argued that cytokine-induced and stress-induced apoptosis act through conceptually similar pathways in which mitochondria are amplifiers of caspase activity rather than initiators of cospase activation.
Journal ArticleDOI
ΔN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
Stéphanie Courtois,Gerald Verhaegh,Sophie North,Sophie North,Maria-Gloria Luciani,Maria-Gloria Luciani,Patrice Lassus,Ula Hibner,Moshe Oren,Pierre Hainaut +9 more
TL;DR: A new isoform, ΔN-p53, produced by internal initiation of translation at codon 40 and lacking the N-terminal first transactivation domain is described, which has impaired transcriptional activation capacity, and does not complex with the p53 regulatory protein Mdm2.
Anti-apoptotic activity oflowlevels ofwild-type p53
TL;DR: In this article, the authors studied the apoptotic response of immortalized mouse fibroblasts to serum withdrawal and found that low levels of the p53 protein can protect from death or promote apoptosis.
Journal ArticleDOI
Anti-apoptotic activity of low levels of wild-type p53
TL;DR: The results indicate that, as a function of its dose, the wild‐type p53 can either protect from death or promote apoptosis, a new, anti‐apoptotic, activity of p53 that may have implications for the understanding of the role played by p53 in embryonic development as well as in initial stages of oncogenesis.
Journal ArticleDOI
Applying ecological and evolutionary theory to cancer: a long and winding road
Frédéric Thomas,Daniel Fisher,Philippe Fort,Jean-Pierre Marie,Simon P. Daoust,Benjamin Roche,Christoph Grunau,Céline Cosseau,Guillaume Mitta,Stephen Baghdiguian,François Rousset,Patrice Lassus,Eric Assenat,Damien Grégoire,Dorothée Missé,Alexander Lorz,Frédérique Billy,W. Vainchenker,François Delhommeau,Serge Koscielny,Raphael Itzykson,Ruoping Tang,Fanny Fava,Annabelle Ballesta,Thomas Lepoutre,Liliana Krasinska,Liliana Krasinska,Vjekoslav Dulic,Vjekoslav Dulic,Peggy Raynaud,Peggy Raynaud,Philippe Blache,Corinne Quittau-Prévostel,Corinne Quittau-Prévostel,Emmanuel Vignal,Emmanuel Vignal,Helene Trauchessec,Benoît Perthame,Jean Clairambault,Vitali Volpert,Eric Solary,Urszula Hibner,Michael E. Hochberg +42 more
TL;DR: The objective of this introduction is to describe the basic ideas and concepts linking evolutionary biology to cancer, and to present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays.