H
Herwig Koppensteiner
Researcher at Heinrich Pette Institute
Publications - 24
Citations - 1799
Herwig Koppensteiner is an academic researcher from Heinrich Pette Institute. The author has contributed to research in topics: JADE (particle detector) & Medicine. The author has an hindex of 15, co-authored 20 publications receiving 1585 citations. Previous affiliations of Herwig Koppensteiner include University of Tübingen & Technische Universität München.
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Journal ArticleDOI
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Julie Lucifora,Yuchen Xia,Florian Reisinger,Ke Zhang,Daniela Stadler,Xiaoming Cheng,Martin F. Sprinzl,Herwig Koppensteiner,Zuzanna Makowska,Tassilo Volz,Caroline Remouchamps,Wen Min Chou,Wolfgang E. Thasler,Norbert Hüser,David Durantel,T. Jake Liang,Carsten Münk,Markus H. Heim,Jeffrey L. Browning,Emmanuel Dejardin,Maura Dandri,Michael Schindler,Mathias Heikenwalder,Ulrike Protzer +23 more
TL;DR: It is described how interferon-α can induce specific degradation of the nuclear viral DNA without hepatotoxicity and proposed lymphotoxin-β receptor activation as a therapeutic alternative and the development of new therapeutics that, in combination with existing antivirals, may cure hepatitis B.
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Macrophages and their relevance in Human Immunodeficiency Virus Type I infection
TL;DR: It is proposed that interaction of HIV-1 with macrophages is crucial during all stages of HIV -1 infection, the development of acquired immunodeficiency syndrome (AIDS) and HIV-associated diseases, including neurocognitive disorders.
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A Flow Cytometry-Based FRET Assay to Identify and Analyse Protein-Protein Interactions in Living Cells
Carina Banning,Joerg Votteler,Dirk Hoffmann,Herwig Koppensteiner,Martin Warmer,Rudolph Reimer,Frank Kirchhoff,Ulrich S. Schubert,Joachim Hauber,Michael Schindler +9 more
TL;DR: A flow cytometry-based FRET assay is developed and analysed interactions of human and simian immunodeficiency virus (HIV and SIV) Nef and Vpu proteins with cellular factors, as well as HIV Rev multimer-formation to allow the identification of novel protein interaction partners in a high-throughput format.
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Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue
Michael Schindler,Devi Rajan,Devi Rajan,Carina Banning,Peter Wimmer,Herwig Koppensteiner,Alicja Iwanski,Anke Specht,Daniel Sauter,Thomas Dobner,Frank Kirchhoff +10 more
TL;DR: The data explain why the effect of the S52A mutation in Vpu on virus release is cell-type dependent and suggest that a reduced ability of Vpu to counteract tetherin impairs HIV-1 replication in macrophages, but not in tissue CD4+ T cells.
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The Root Extract of the Medicinal Plant Pelargonium sidoides Is a Potent HIV-1 Attachment Inhibitor
Markus Helfer,Herwig Koppensteiner,Martha Schneider,Stephanie Rebensburg,Sara Forcisi,Constanze Müller,Philippe Schmitt-Kopplin,Michael Schindler,Ruth Brack-Werner +8 more
TL;DR: It is proposed that PS extract represents a lead candidate for the development of a scientifically validated herbal medicine for anti-HIV-1 therapy with a mode-of-action different from and complementary to current single-molecule drugs.