Daniel Sauter

TL;DR: Only HIV-1 M evolved a fully functional Vpu following the three independent cross-species transmissions that resulted in HIV- 1 groups M, N, and O, which may explain why group M viruses are almost entirely responsible for the global HIV/AIDS pandemic.

TL;DR: These findings not only help to explain the poor interferon response in COVID-19 patients, but also describe the emergence of natural SARS-CoV-2 quasispecies with an extended ORF3b gene that may potentially affect CO VID-19 pathogenesis.

TL;DR: The physiological and pathophysiological substrates of furin are described and how dysregulation of a simple proteolytic cleavage event may promote infectious diseases and cancer are discussed.

TL;DR: SAMHD1 experienced strong positive selection episodes during primate evolution that occurred in the Catarrhini ancestral branch prior to the separation between hominoids and great apes and Old World monkeys, and antagonism of SAMHD1 by Vpx is species-specific.

TL;DR: The results identify GBP5 as an antiviral effector of the IFN response and may explain the increased frequency of defective vpu genes in primary HIV-1 strains.