H
Hetal N. Patel
Researcher at University of California, San Francisco
Publications - 2
Citations - 3019
Hetal N. Patel is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Melanoma & Gene. The author has an hindex of 2, co-authored 2 publications receiving 2853 citations.
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Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TL;DR: The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.
Journal ArticleDOI
Determinants of BRAF Mutations in Primary Melanomas
Janet L. Maldonado,Jane Fridlyand,Hetal N. Patel,Ajay N. Jain,Klaus J. Busam,Toshiro Kageshita,Tomomichi Ono,Donna G. Albertson,Daniel Pinkel,Boris C. Bastian +9 more
TL;DR: The uneven distribution of BRAF mutations strongly suggests distinct genetic pathways leading to melanoma, and the high mutation frequency in melanomas arising on intermittently sun-exposed skin suggests a complex causative role of such exposure that mandates further evaluation.