H
Hideki Fujii
Researcher at Osaka City University
Publications - 95
Citations - 3729
Hideki Fujii is an academic researcher from Osaka City University. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Fatty liver. The author has an hindex of 28, co-authored 95 publications receiving 2678 citations.
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Journal ArticleDOI
Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis
Jie Li,Jie Li,Biyao Zou,Yee Hui Yeo,Yuemin Feng,Xiaoyu Xie,Dong Hyun Lee,Hideki Fujii,Yuankai Wu,Yuankai Wu,Leslie Y. Kam,Fanpu Ji,Fanpu Ji,Xiaohe Li,Nicholas Chien,Mike Wei,Eiichi Ogawa,Eiichi Ogawa,Changqing Zhao,Xia Wu,Xia Wu,Christopher D Stave,Linda Henry,Scott D. Barnett,Hirokazu Takahashi,Norihiro Furusyo,Yuichiro Eguchi,Yao-Chun Hsu,Teng-Yu Lee,Wanhua Ren,Chengyong Qin,Dae Won Jun,Hidenori Toyoda,Vincent Wai-Sun Wong,Ramsey Cheung,Ramsey Cheung,Qiang Zhu,Mindie H. Nguyen +37 more
TL;DR: NAFLD prevalence in Asia is increasing and is associated with poor outcomes including hepatocellular carcinoma and death, especially in high-risk groups, such as older obese men, and targeted public health strategies must be developed in Asia.
Journal ArticleDOI
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
Yoshio Sumida,Masato Yoneda,Hideyuki Hyogo,Yoshito Itoh,Masafumi Ono,Hideki Fujii,Yuichiro Eguchi,Yasuaki Suzuki,Noriaki Aoki,Kazuyuki Kanemasa,Koji Fujita,Kazuaki Chayama,Toshiji Saibara,Norifumi Kawada,Kazuma Fujimoto,Yutaka Kohgo,Toshikazu Yoshikawa,Takeshi Okanoue +17 more
TL;DR: The FIB4 index was superior to other tested noninvasive markers of fibrosis in Japanese patients with NAFLD, with a high negative predictive value for excluding advanced fibrosis.
Journal ArticleDOI
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
Tomohiro Ogawa,Tomohiro Ogawa,Masaru Enomoto,Hideki Fujii,Yumiko Sekiya,Katsutoshi Yoshizato,Kazuo Ikeda,Norifumi Kawada +7 more
TL;DR: Among these miRNAs, miR-221/222 were upregulated in LX-2 cells and increased during the course of culture-dependent activation of mouse primary stellate cells, in a manner similar to the expression of α1(I) collagen and α-smooth muscle actin mRNAs.
Journal ArticleDOI
A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease
Yoshio Sumida,Masato Yoneda,Hideyuki Hyogo,Kanji Yamaguchi,Masafumi Ono,Hideki Fujii,Yuichiro Eguchi,Yasuaki Suzuki,Shunsuke Imai,Kazuyuki Kanemasa,Koji Fujita,Kazuaki Chayama,Kohichiroh Yasui,Toshiji Saibara,Norifumi Kawada,Kazuma Fujimoto,Yutaka Kohgo,Takeshi Okanoue +17 more
TL;DR: NAFIC score can predict NASH in Japanese NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use.
Journal ArticleDOI
Erythrophagocytosis by Liver Macrophages (Kupffer Cells) Promotes Oxidative Stress, Inflammation, and Fibrosis in a Rabbit Model of Steatohepatitis: Implications for the Pathogenesis of Human Nonalcoholic Steatohepatitis
Kohji Otogawa,Kohji Kinoshita,Hideki Fujii,Masahide Sakabe,Ryoko Shiga,Kazuki Nakatani,Kazuo Ikeda,Yuji Nakajima,Yoshihiro Ikura,Makiko Ueda,Tetsuo Arakawa,Fumihiko Hato,Norifumi Kawada +12 more
TL;DR: The results indicate that the engulfment of PS-externalized, apoptotic signal-positive, erythrocytes by hepatic macrophages may lead to the deposition of iron derived from hemoglobin in the liver and be involved in the pathogenesis of steatohepatitis.