Hideki Kishikawa

TL;DR: It is concluded that the two nuclear proteins that bind to the E box regulate IRS-1 gene expression positively in HepG2 cells and the twonuclear proteins thatbind to the C/EBP binding site regulate it negatively in CHO cells.

TL;DR: The results suggest that both GLUT2 and glucokinase are necessary for the glucose stimulated insulin secretion in at least rodent cell lines, and that other element(s) are needed for a biphasic insulin secretion typically observed in beta cells.

TL;DR: It is suggested that plasma epinephrine plays an important role in platelet activation during hypoglycaemia in Type 2 diabetes mellitus, and that the plateletactivation is prevented by α2-adrenoceptor antagonist.

TL;DR: The results suggest that epinephrine is responsible for some, if not all, of the β-TG release from the platelets during insulin-induced hypoglycemia.

TL;DR: Results clearly demonstrated that bradykinin enhanced insulin-stimulated tyrosine kinase activity of the insulin receptor and downstream insulin signal cascade through the BK2R mediated signal pathway.