N
Noboru Furukawa
Researcher at Kumamoto University
Publications - 42
Citations - 1295
Noboru Furukawa is an academic researcher from Kumamoto University. The author has contributed to research in topics: Insulin & Type 2 diabetes. The author has an hindex of 20, co-authored 42 publications receiving 1161 citations. Previous affiliations of Noboru Furukawa include Harvard University.
Papers
More filters
Journal ArticleDOI
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle *
Tonya L. Martin,Thierry Alquier,Kenji Asakura,Noboru Furukawa,Frédéric Preitner,Barbara B. Kahn +5 more
TL;DR: DIO in FVB mice alters α2-AMPK in muscle and hypothalamus and STAT3 in hypothalamic and impairs further effects of leptin on these signaling pathways and may contribute to resistance to leptin action on food intake and energy expenditure in obese states.
Journal ArticleDOI
Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.
Kaku Tsuruzoe,Eiichi Araki,Noboru Furukawa,Tetsuya Shirotani,Kazuya Matsumoto,Kengo Kaneko,Hiroyuki Motoshima,Kazuaki Yoshizato,Atsuhisa Shirakami,Hideki Kishikawa,Jun-ichi Miyazaki,Motoaki Shichiri +11 more
TL;DR: In this paper, a MIN6 cell line that depleted mtDNA by treatment with ethidium bromide (EtBr) was created, and the response of the cell line to various secretagogues.
Journal ArticleDOI
Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues
Bingzhong Xue,Thomas Pulinilkunnil,Incoronata Murano,Kendra K. Bence,Huamei He,Yasuhiko Minokoshi,Kenji Asakura,Anna Lee,Fawaz G. Haj,Noboru Furukawa,Karyn J. Catalano,Mirela Delibegovic,James A. Balschi,Saverio Cinti,Benjamin G. Neel,Barbara B. Kahn +15 more
TL;DR: The mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues.
Journal ArticleDOI
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis
Hironori Adachi,Yukio Fujiwara,Tatsuya Kondo,Takeshi Nishikawa,Rei Ogawa,Takeshi Matsumura,Norio Ishii,Ryoji Nagai,Keishi Miyata,Mitsuhisa Tabata,Hiroyuki Motoshima,Noboru Furukawa,Kaku Tsuruzoe,Junji Kawashima,Motohiro Takeya,Shizuya Yamashita,Gou Young Koh,Andras Nagy,Toshio Suda,Yuichi Oike,Eiichi Araki +20 more
TL;DR: A genetic knockout of Angptl 4 protects ApoE(-/-) mice against development and progression of atherosclerosis and strongly suppresses the ability of the macrophages to become foam cells in vitro.
Journal ArticleDOI
A high-fat, ketogenic diet induces a unique metabolic state in mice (American Journal of Physiology - Endocrinology and Metabolism (2007) 292, 55, (E1724-E1739))
A Kennedy,Pavlos Pissios,Hasan H. Otu,R. Roberson,Bingzhong Xue,Kenji Asakura,Noboru Furukawa,Francis E. Marino,Fen-Fen Liu,Barbara B. Kahn,Towia A. Libermann,Eleftheria Maratos-Flier +11 more