K
Kaku Tsuruzoe
Researcher at Kumamoto University
Publications - 25
Citations - 923
Kaku Tsuruzoe is an academic researcher from Kumamoto University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 16, co-authored 25 publications receiving 883 citations.
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Journal ArticleDOI
Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling.
Koujiro Imoto,Daisuke Kukidome,Takeshi Nishikawa,Takako Matsuhisa,Kazuhiro Sonoda,Kazuo Fujisawa,Miyuki Yano,Hiroyuki Motoshima,Tetsuya Taguchi,Kaku Tsuruzoe,Takeshi Matsumura,Hidenori Ichijo,Eiichi Araki +12 more
TL;DR: The results suggest that TNF-α increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these T NF-α–induced phenomena contribute, at least in part, to impaired insulin signaling.
Journal ArticleDOI
Enhanced expression of PDX-1 and Ngn3 by exendin-4 during β cell regeneration in STZ-treated mice
Shoko Kodama,Tetsushi Toyonaga,Tatsuya Kondo,K. Matsumoto,Kaku Tsuruzoe,Junji Kawashima,Hideo Goto,Kazuhiko Kume,Shoen Kume,Michiharu Sakakida,Eiichi Araki +10 more
TL;DR: Recovering beta cell regeneration seemed to occur mainly from intra-islet stem/progenitor cells, which paralleled increased IRS-2 expression and translocation of Foxo1 from nucleus to cytoplasm.
Journal ArticleDOI
Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.
Kaku Tsuruzoe,Eiichi Araki,Noboru Furukawa,Tetsuya Shirotani,Kazuya Matsumoto,Kengo Kaneko,Hiroyuki Motoshima,Kazuaki Yoshizato,Atsuhisa Shirakami,Hideki Kishikawa,Jun-ichi Miyazaki,Motoaki Shichiri +11 more
TL;DR: In this paper, a MIN6 cell line that depleted mtDNA by treatment with ethidium bromide (EtBr) was created, and the response of the cell line to various secretagogues.
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Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis
Hironori Adachi,Yukio Fujiwara,Tatsuya Kondo,Takeshi Nishikawa,Rei Ogawa,Takeshi Matsumura,Norio Ishii,Ryoji Nagai,Keishi Miyata,Mitsuhisa Tabata,Hiroyuki Motoshima,Noboru Furukawa,Kaku Tsuruzoe,Junji Kawashima,Motohiro Takeya,Shizuya Yamashita,Gou Young Koh,Andras Nagy,Toshio Suda,Yuichi Oike,Eiichi Araki +20 more
TL;DR: A genetic knockout of Angptl 4 protects ApoE(-/-) mice against development and progression of atherosclerosis and strongly suppresses the ability of the macrophages to become foam cells in vitro.
Journal ArticleDOI
Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling
Ryohei Yoshimura,Eiichi Araki,Sachiko Ura,Mikio Todaka,Kaku Tsuruzoe,Noboru Furukawa,Hiroyuki Motoshima,Kazuaki Yoshizato,Kengo Kaneko,Kohji Matsuda,Hideki Kishikawa,Motoaki Shichiri +11 more
TL;DR: The data suggest that the impaired mitogenic response of P170R and m209T was mainly due to reduced binding to the insulin receptor, whereas the impaired response of G971R was mainlydue to reduced association with PI 3-kinase p85.