C
Changli Wei
Researcher at Rush University Medical Center
Publications - 77
Citations - 6208
Changli Wei is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: SuPAR & Focal segmental glomerulosclerosis. The author has an hindex of 32, co-authored 69 publications receiving 5434 citations. Previous affiliations of Changli Wei include Harvard University & University of Miami.
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Journal ArticleDOI
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Jochen Reiser,Krishna R. Polu,Clemens C. Möller,Peter Kenlan,Mehmet M. Altintas,Changli Wei,Christian Faul,Stephanie Herbert,Ivan Villegas,Carmen Avila-Casado,Mary McGee,Hikaru Sugimoto,Dennis Brown,Raghu Kalluri,Peter Mundel,Paula Smith,David E. Clapham,Martin R. Pollak +17 more
TL;DR: It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm.
Journal ArticleDOI
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
Changli Wei,Shafic El Hindi,Jing Li,Alessia Fornoni,Nelson Goes,Junichiro Sageshima,Dony Maiguel,S. Ananth Karumanchi,Hui-Kim Yap,Moin A. Saleem,Qing-Yin Zhang,Boris Nikolic,Abanti Chaudhuri,Pirouz Daftarian,Eduardo Salido,Armando Torres,Moro O. Salifu,Minnie M. Sarwal,Franz Schaefer,Christian Morath,Vedat Schwenger,Martin Zeier,Vineet Gupta,David M. Roth,Maria Pia Rastaldi,George W. Burke,Phillip Ruiz,Jochen Reiser +27 more
TL;DR: It is reported that serum soluble urokinase receptor (suPAR) is elevated in two-thirds of subjects with primary FSGS, but not in people with other glomerular diseases, and that a higher concentration of suPAR before transplantation underlies an increased risk for recurrence of FSGS after transplantation.
Journal ArticleDOI
Modification of kidney barrier function by the urokinase receptor
Changli Wei,Clemens C. Möller,Mehmet M. Altintas,Jing Li,Karin Schwarz,Serena Zacchigna,Liang Xie,Anna Henger,Holger Schmid,Maria Pia Rastaldi,Peter J. Cowan,Matthias Kretzler,Roberto L. Parrilla,Moise Bendayan,Vineet Gupta,Boris Nikolic,Raghu Kalluri,Peter Carmeliet,Peter Mundel,Jonche Reiser +19 more
TL;DR: It is shown that induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via a mechanism that includes lipid-dependent activation of αvβ3 integrin.
Journal ArticleDOI
Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis
Alessia Fornoni,Junichiro Sageshima,Changli Wei,Sandra Merscher-Gomez,Robier Aguillon-Prada,Alexandra Jauregui,Jing Li,Adela Mattiazzi,Gaetano Ciancio,Linda Chen,Gaston Zilleruelo,Carolyn Abitbol,Jayanthi Chandar,Wacheree Seeherunvong,Camillo Ricordi,Masami Ikehata,Maria Pia Rastaldi,Jochen Reiser,George W. Burke +18 more
TL;DR: Modulation of sphingolipid-related proteins plays a role in the pathogenesis of recurrent FSGS and, moreover, that these proteins and enzymes might be targets of rituximab treatment.
Journal ArticleDOI
Soluble Urokinase Receptor and Chronic Kidney Disease
Salim S. Hayek,Sanja Sever,Yi-An Ko,Howard Trachtman,Mosaab Awad,Shikha Wadhwani,Mehmet M. Altintas,Changli Wei,Anna L. Hotton,Audrey L. French,Laurence S. Sperling,Stamatios Lerakis,Arshed A. Quyyumi,Jochen Reiser +13 more
TL;DR: An elevated level of suPAR was independently associated with incident chronic kidney disease and an accelerated decline in the eGFR in the groups studied.