H
Hilary A. Coller
Researcher at University of California, Los Angeles
Publications - 103
Citations - 28264
Hilary A. Coller is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Cell cycle & Cellular differentiation. The author has an hindex of 40, co-authored 95 publications receiving 25863 citations. Previous affiliations of Hilary A. Coller include Rutgers University & University of California.
Papers
More filters
Journal ArticleDOI
Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer.
TL;DR: One of the clusters was enriched in the non-basal PAM50 subtypes, exhibited more aggressive clinical features and had a distinctive signature of oncogenic mutations, miRNAs and expressed genes.
Journal ArticleDOI
Quiescent fibroblasts are protected from proteasome inhibition–mediated toxicity
Aster Legesse-Miller,Irene Raitman,Erin M. Haley,Albert Liao,Lova Sun,David J. Wang,Nithya Krishnan,Johanna M.S. Lemons,Eric J. Suh,Elizabeth L. Johnson,Benjamin A. Lund,Hilary A. Coller +11 more
TL;DR: Mechanisms that protect quiescent fibroblasts include autophagy/lysosomal pathways, diminished aggresome formation, and detoxification of reactive oxygen species.
Journal ArticleDOI
Fetal–juvenile origins of point mutations in the adult human tracheal–bronchial epithelium: Absence of detectable effects of age, gender or smoking status
Hiroko Sudo,Xiao Cheng Li-Sucholeiki,Luisa A. Marcelino,Luisa A. Marcelino,Amanda N. Gruhl,Pablo Herrero-Jimenez,Helmut Zarbl,James C. Willey,Emma E. Furth,Stephan Morgenthaler,Hilary A. Coller,Hilary A. Coller,Per Olaf Ekstrøm,Raymond C. Kurzweil,Elena V. Gostjeva,William G. Thilly +15 more
TL;DR: A parsimonious interpretation of these nuclear and previously reported data for lung epithelial mitochondrial point mutant clusters is that they arose from mutations in stem cells at a high but constant rate per stem cell doubling during at least ten stem cell doublings of the later fetal-juvenile period.
Book ChapterDOI
An In Vitro Model of Cellular Quiescence in Primary Human Dermal Fibroblasts
TL;DR: An in vitro model of quiescence that is based on neonatal human dermal fibroblasts based on antiproliferative signals, contact inhibition, and serum-starvation (mitogen withdrawal) is described.
Journal ArticleDOI
Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium.
Hilary A. Coller,Konstantin Khrapko,Pablo Herrero-Jimenez,Janice A. Vatland,Xiao-Cheng Li-Sucholeiki,William G. Thilly +5 more
TL;DR: The bulk of the data were best explained by a model in which most stem cells, defined here as long-lived cells, give rise to colonies of approximately 8-128 cells, which suggest the bronchial epithelium may contain large clusters of cells with mutations, and possibly phenotypic alterations as well.