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Hilary Linda Hoare
Researcher at Monash University, Clayton campus
Publications - 6
Citations - 706
Hilary Linda Hoare is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Human leukocyte antigen & Receptor. The author has an hindex of 6, co-authored 6 publications receiving 625 citations. Previous affiliations of Hilary Linda Hoare include Monash University.
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Journal ArticleDOI
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence
Emma J. Petrie,Craig Steven Clements,Jie Lin,Lucy C. Sullivan,Darryl N. Johnson,Trevor Huyton,Annie Heroux,Hilary Linda Hoare,Travis Clarke Beddoe,Hugh H. Reid,Matthew C.J. Wilce,Andrew G. Brooks,Jamie Rossjohn +12 more
TL;DR: Differences in the docking strategies used by the NKG2D and CD94-NKG2A receptors provided a basis for understanding the promiscuous nature of ligand recognition by NKg2D compared with the fidelity of the CD 94-NKg2 receptors.
Journal ArticleDOI
Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface
Craig Steven Clements,Lars Kjer-Nielsen,Lyudmila Kostenko,Hilary Linda Hoare,Michelle A. Dunstone,Eric K. Moses,Katy A. Freed,Andrew G. Brooks,Jamie Rossjohn,James McCluskey +9 more
TL;DR: The alpha3 domain of HLA-G, a candidate binding site for the LIR-1 and -2 inhibitory receptors, is structurally distinct from the alpha3 domains of classical MHC-I molecules, providing a rationale for the observed affinity differences for these ligands.
Journal ArticleDOI
Structural basis for a major histocompatibility complex class Ib–restricted T cell response
Hilary Linda Hoare,Lucy C. Sullivan,Gabriella Pietra,Gabriella Pietra,Craig Steven Clements,Eleanor J Lee,Lauren Kate Ely,Travis Clarke Beddoe,Michela Falco,Lars Kjer-Nielsen,Hugh H. Reid,James McCluskey,Lorenzo Moretta,Lorenzo Moretta,Jamie Rossjohn,Andrew G. Brooks +15 more
TL;DR: The results emphasize the evolutionary 'ambiguity' of HLA-E, which not only interacts with innate immune receptors but also has the functional capacity to mediate virus-specific cytotoxic T lymphocyte responses during adaptive immunity.
Journal ArticleDOI
Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94–NKG2 Natural Killer Cell Receptors
Hilary Linda Hoare,Lucy C. Sullivan,Craig Steven Clements,Lauren Kate Ely,Travis Clarke Beddoe,Kate Henderson,Jie Lin,Hugh H. Reid,Andrew G. Brooks,Jamie Rossjohn +9 more
TL;DR: The data indicate that the CD94-NKG2 receptors interact with HLA-E in a manner that maximises the ability of the receptors to discriminate between subtle changes in both the sequence and conformation of peptides bound to Hla-E.
Journal ArticleDOI
The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.
Lucy C. Sullivan,Craig Steven Clements,Travis Clarke Beddoe,Darryl N. Johnson,Hilary Linda Hoare,Jie Lin,Trevor Huyton,Emma June Hopkins,Hugh H. Reid,Matthew C.J. Wilce,Juraj Kabat,Francisco Borrego,John E. Coligan,Jamie Rossjohn,Andrew G. Brooks +14 more
TL;DR: This work describes the 2.5 A resolution crystal structure of CD94-NKG2A in which the mode of dimerization contrasts with that of other homodimeric NK receptors, and indicates that the dimer interface is asymmetric, thereby providing a structural basis for the preferred heterodimerics assembly.