H
Himanshu Kumar
Researcher at Indian Institute of Science
Publications - 127
Citations - 11986
Himanshu Kumar is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 32, co-authored 97 publications receiving 10353 citations. Previous affiliations of Himanshu Kumar include Osaka University & Indian Institute of Science Education and Research, Bhopal.
Papers
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Journal ArticleDOI
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai,Ken Takahashi,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken Ishii,Osamu Takeuchi,Shizuo Akira +9 more
TL;DR: IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection and blocked interferon induction by virus infection.
Journal ArticleDOI
Pathogen Recognition by the Innate Immune System
TL;DR: In this review, a comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated byPRRs.
Journal ArticleDOI
Toll-like receptors and innate immunity
TL;DR: The recent advances in pathogen recognition by TLRs and TLR signaling are described and their roles in shaping pathogen-specific humoral and cellular adaptive immune responses are described.
Proceedings Article
Robust Loss Functions under Label Noise for Deep Neural Networks
TL;DR: This paper provides some sufficient conditions on a loss function so that risk minimization under that loss function would be inherently tolerant to label noise for multiclass classification problems, and generalizes the existing results on noise-tolerant loss functions for binary classification.
Journal ArticleDOI
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ken Ishii,Tatsukata Kawagoe,Shohei Koyama,Kosuke Matsui,Himanshu Kumar,Taro Kawai,Satoshi Uematsu,Osamu Takeuchi,Fumihiko Takeshita,Cevayir Coban,Shizuo Akira +10 more
TL;DR: It is demonstrated in vivo that TANK-binding kinase 1 (TBK1), a non-canonical IκB kinase, mediates the adjuvant effect of DNA vaccines and is essential for its immunogenicity in mice.