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Journal ArticleDOI

Toll-like receptors and innate immunity

Himanshu Kumar, +2 more
- 30 Oct 2009 - 
- Vol. 388, Iss: 4, pp 621-625
TLDR
The recent advances in pathogen recognition by TLRs and TLR signaling are described and their roles in shaping pathogen-specific humoral and cellular adaptive immune responses are described.
About: 
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2009-10-30. It has received 1112 citations till now. The article focuses on the topics: Pattern recognition receptor & Immune receptor.

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Citations
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Journal ArticleDOI

Toll-like receptors.

Kiyoshi Takeda, +2 more
- 28 Nov 2003 - 
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI

Pathogen Recognition by the Innate Immune System

Himanshu Kumar, +2 more
- 14 Jan 2011 - 
TL;DR: In this review, a comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated byPRRs.
Journal ArticleDOI

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Muller Fabbri, +18 more
- 31 Jul 2012 - 
TL;DR: It is shown that tumor-secreted miR-21 andmiR-29a also can function by another mechanism, by binding as ligands to receptors of the Toll-like receptor (TLR) family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response that ultimately may lead to tumor growth and metastasis.
Journal ArticleDOI

Intracellular Toll-like Receptors

Amanda L. Blasius, +1 more
- 26 Mar 2010 - 
TL;DR: The latest findings on the intracellular Toll-like receptors are reviewed, with special emphasis on ligand uptake, receptor trafficking, signaling, and regulation.
Journal ArticleDOI

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Christopher K. Glass, +1 more
- 02 May 2012 - 
TL;DR: Recent findings related to this interconnected network of eicosanoids and inositol phospholipids are reviewed from the perspective of immunity and metabolic disease.
References
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Journal ArticleDOI

Pathogen Recognition and Innate Immunity

Shizuo Akira, +2 more
- 24 Feb 2006 - 
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI

Innate Immune Recognition

Charles A. Janeway, +1 more
- 01 Jan 2002 - 
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Journal ArticleDOI

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Alexander Poltorak, +13 more
- 11 Dec 1998 - 
TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
Journal Article

Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene

Alexander Poltorak, +13 more
- 01 Jan 1999 - 
Journal ArticleDOI

A Toll-like receptor recognizes bacterial DNA.

Hiroaki Hemmi, +10 more
- 07 Dec 2000 - 
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.