H
Himanshu Kumar
Researcher at Indian Institute of Science
Publications - 127
Citations - 11986
Himanshu Kumar is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 32, co-authored 97 publications receiving 10353 citations. Previous affiliations of Himanshu Kumar include Osaka University & Indian Institute of Science Education and Research, Bhopal.
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Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses
TL;DR: It is shown that the adjuvant effects of poly IC require a cooperative activation of TLR and cytoplasmic RNA helicase pathways, and the double deficiency resulted in a complete loss of Ab production.
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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
Zachary J. Roberts,Nadege Goutagny,Pin Yu Perera,Hiroki Kato,Himanshu Kumar,Taro Kawai,Shizuo Akira,Ram Savan,David Van Echo,Katherine A. Fitzgerald,Howard A. Young,Lai-Ming Ching,Stefanie N. Vogel +12 more
TL;DR: The data demonstrate that 5,6-dimethylxanthenone-4-acetic acid is a novel and specific activator of the TANK-binding kinase 1 (TBK1)–interferon (IFN) regulatory factor 3 (IRF-3) signaling pathway and detail a novel pathway for TBK1-mediated IRF- 3 activation.
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The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication
Harshad Ingle,Sushil Kumar,Ashwin Ashok Raut,Anamika Mishra,Diwakar D. Kulkarni,Takeshi Kameyama,Akinori Takaoka,Shizuo Akira,Himanshu Kumar,Himanshu Kumar +9 more
TL;DR: Inhibition of the expression of mir-485 markedly reduced the replication of Newcastle disease virus and the H5N1 strain of influenza virus in mammalian cells, highlighting the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection.
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Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88
Andreas Jung,Hiroki Kato,Yutaro Kumagai,Himanshu Kumar,Taro Kawai,Osamu Takeuchi,Shizuo Akira +6 more
TL;DR: Results suggest that recognition of LCMV by plasmacytoid DCs via TLRs is responsible for the production of type I IFNs in vivo, and the activation of a MyD88-dependent innate mechanism induces a CTL response, which eventually leads to virus elimination.
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Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways
Tohru Miyake,Yutaro Kumagai,Hiroki Kato,Zijin Guo,Kazufumi Matsushita,Takashi Satoh,Tatsukata Kawagoe,Himanshu Kumar,Myoung Ho Jang,Taro Kawai,Tohru Tani,Osamu Takeuchi,Shizuo Akira +12 more
TL;DR: It is demonstrated that the IPS-1-dependent and the TRIF-dependent pathways are essential for NK cell activation to poly I:C stimulation in mice, whereas deficiency in eitherIPS-1 or TRIF only modestly impairs the poly I :C-induced NK cellactivation.