H
Hinrich Gronemeyer
Researcher at French Institute of Health and Medical Research
Publications - 25
Citations - 1266
Hinrich Gronemeyer is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Chromatin & Transcription factor. The author has an hindex of 14, co-authored 25 publications receiving 946 citations. Previous affiliations of Hinrich Gronemeyer include University of Strasbourg.
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Journal ArticleDOI
Senescence-associated reprogramming promotes cancer stemness
Maja Milanovic,Dorothy N. Y. Fan,Dimitri Belenki,J. Henry M. Däbritz,Zhen Zhao,Yong Yu,Jan Dörr,Lora Dimitrova,Dido Lenze,Inês Am Barbosa,Marco A. Mendoza-Parra,Tamara Kanashova,Marlen Metzner,Katharina Pardon,Maurice Reimann,Andreas Trumpp,Bernd Dörken,Johannes Zuber,Hinrich Gronemeyer,Michael Hummel,Gunnar Dittmar,Soyoung Lee,Clemens A. Schmitt +22 more
TL;DR: Senescence-associated stemness is an unexpected, cell-autonomous feature that exerts its detrimental, highly aggressive growth potential upon escape from cell-cycle blockade, and is enriched in relapse tumours.
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Single-tube linear DNA amplification (LinDA) for robust ChIP-seq
Pattabhiraman Shankaranarayanan,Marco Antonio Mendoza-Parra,Mannu Walia,Li Wang,Ning Li,Luisa M. Trindade,Hinrich Gronemeyer +6 more
TL;DR: A high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP- sequencing with picogram DNA amounts obtained from a few thousand cells will facilitate global analyses of transcription-factor binding and chromatin with very small cell populations, such as stem or cancer-initiating cells.
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The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer
Ronan Chaligne,Tatiana Popova,Tatiana Popova,Marco Antonio Mendoza-Parra,Mohamed-Ashick M. Saleem,David Gentien,Kristen A. Ban,Tristan Piolot,Olivier Leroy,Odette Mariani,Hinrich Gronemeyer,Anne Vincent-Salomon,Marc-Henri Stern,Marc-Henri Stern,Edith Heard +14 more
TL;DR: This study provides the first integrated analysis of the inactive X chromosome in the context of breast cancer and establishes that epigenetic erosion of the active X can lead to the disappearance of the Barr body in breast cancer cells.
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Dissecting the retinoid‐induced differentiation of F9 embryonal stem cells by integrative genomics
TL;DR: A dynamic view of RA signalling during cell differentiation is provided, which reveals RAR heterodimer dynamics and promiscuity, and predicts decisions that diversify the RA signal into distinct gene‐regulatory programs.
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A quality control system for profiles obtained by ChIP sequencing
Marco Antonio Mendoza-Parra,Wouter Van Gool,Mohamed Ashick Mohamed Saleem,Danilo Guillermo Ceschin,Hinrich Gronemeyer +4 more
TL;DR: An approach that associates global and local QC indicators to ChIP-seq data sets as well as to a variety of enrichment-based studies by NGS, which may significantly improve multidimensional comparisons that have great promise for extracting information from combinatorial analyses.