R
Ronan Chaligne
Researcher at Cornell University
Publications - 57
Citations - 1921
Ronan Chaligne is an academic researcher from Cornell University. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 17, co-authored 31 publications receiving 1198 citations. Previous affiliations of Ronan Chaligne include University of Paris & Curie Institute.
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Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
TL;DR: This Review discusses the application of single-cell multi-omics technologies to the study of cancer evolution, which capture and integrate the different layers of heritable information and reveal their complex interplay.
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Somatic mutations and cell identity linked by Genotyping of Transcriptomes
Anna S. Nam,Kyu-Tae Kim,Ronan Chaligne,Franco Izzo,Chelston Ang,Justin Taylor,Robert M. Myers,Ghaith Abu-Zeinah,Ryan M. Brand,Nathaniel D. Omans,Alicia Alonso,Caroline Sheridan,Marisa Mariani,Xiaoguang Dai,Eoghan D. Harrington,Alessandro Pastore,Juan R. Cubillos-Ruiz,Wayne Tam,Ronald Hoffman,Raul Rabadan,Joseph M. Scandura,Omar Abdel-Wahab,Peter Smibert,Dan A. Landau +23 more
TL;DR: Genotyping of Transcriptomes (GoT) is developed, a method to integrate genotyping with high-throughput droplet-based single-cell RNA sequencing that reveals that the transcriptional output of somatic mutations in myeloproliferative neoplasms is dependent on the native cell identity.
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Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia.
Federico Gaiti,Ronan Chaligne,Hongcang Gu,Ryan M. Brand,Steven Kothen-Hill,Rafael C. Schulman,Kirill Grigorev,Davide Risso,Davide Risso,Kyu-Tae Kim,Alessandro Pastore,Kevin Y. Huang,Alicia Alonso,Caroline Sheridan,Nathaniel D. Omans,Evan Biederstedt,Kendell Clement,Lili Wang,Joshua Felsenfeld,Erica B. Bhavsar,Martin J. Aryee,Martin J. Aryee,John N. Allan,Richard R. Furman,Andreas Gnirke,Catherine J. Wu,Catherine J. Wu,Alexander Meissner,Alexander Meissner,Dan A. Landau +29 more
TL;DR: A single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution during treatment with ibrutinib.
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DNA methylation disruption reshapes the hematopoietic differentiation landscape
Franco Izzo,Stanley Chun-Wei Lee,Stanley Chun-Wei Lee,Asaf Poran,Ronan Chaligne,Federico Gaiti,Baptiste Gross,Rekha R. Murali,Sunil Deochand,Chelston Ang,Philippa Wyndham Jones,Anna S. Nam,Kyu-Tae Kim,Steven Kothen-Hill,Rafael C. Schulman,Michelle Ki,Priscillia Lhoumaud,Jane A. Skok,Aaron D. Viny,Ross L. Levine,Ephraim Kenigsberg,Omar Abdel-Wahab,Dan A. Landau +22 more
TL;DR: Data show that DNAme shapes the topography of hematopoietic differentiation, and support a model in which genome-wide methylation changes are transduced to differentiation skews through biases in CpG enrichment of the transcription factor binding motifs.
Journal ArticleDOI
X-chromosome inactivation in development and cancer
Ronan Chaligne,Edith Heard +1 more
TL;DR: Current knowledge on the epigenetic changes that accompany X inactivation are summarized and the extent to which the inactive X chromosome may be epigenetically or genetically perturbed in breast cancer is discussed.