H
Hiroaki Sasai
Researcher at Osaka University
Publications - 293
Citations - 9623
Hiroaki Sasai is an academic researcher from Osaka University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 50, co-authored 278 publications receiving 9019 citations. Previous affiliations of Hiroaki Sasai include University of Burgundy & University of Tokyo.
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Enantioselective Morita–Baylis–Hillman (MBH) reaction promoted by a heterobimetallic complex with a Lewis base
TL;DR: In this paper, a new double-activation catalysis was presented for the MBH reaction of an α,β-unsaturated ketone and an aldehyde by the combined use of a heterobimetallic asymmetric complex and tributylphosphine ((n-Bu)3P) to afford the α-methylene-β-hydroxy ketone with up to 99% ee.
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Catalytic asymmetric synthesis of arbutamine
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Chlorinative Cyclization of 1,6-Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis
TL;DR: In this article, a chiral spiro bis(isoxazoline) ligand (SPRIX) was used for asymmetric catalysis via a palladium(II)/palladium(IV) cycle.
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Pd-catalyzed 5-endo-trig-type cyclization of β,γ-unsaturated carbonyl compounds: an efficient ring closing reaction to give γ-butenolides and 3-pyrrolin-2-ones
Gan B. Bajracharya,Priti S. Koranne,R. N. Nadaf,Randa Kassem Mohamed Gabr,Kazuhiro Takenaka,Shinobu Takizawa,Hiroaki Sasai +6 more
TL;DR: The 5-endo-trig-type cyclization of β,γ-unsaturated carbonyl compounds gave γ-butenolides and 3-pyrrolin-2-ones in good to excellent yields.
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Phosphine-Catalyzed Dual Umpolung Domino Michael Reaction: Facile Synthesis of Hydroindole- and Hydrobenzofuran-2-Carboxylates
TL;DR: A highly atom-economical, chemoselective, and stereoselectives Lewis base (LB)-catalyzed dual umpolung domino Michael reaction between cyclohexadienones and alkynyl esters has been developed.