H
Hiroaki Sasai
Researcher at Osaka University
Publications - 293
Citations - 9623
Hiroaki Sasai is an academic researcher from Osaka University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 50, co-authored 278 publications receiving 9019 citations. Previous affiliations of Hiroaki Sasai include University of Burgundy & University of Tokyo.
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Journal ArticleDOI
Exploration of flow reaction conditions using machine-learning for enantioselective organocatalyzed Rauhut–Currier and [3+2] annulation sequence
Masaru Kondo,H. D. P. Wathsala,Makoto Sako,Yutaro Hanatani,Kazunori Ishikawa,Satoshi Hara,Takayuki Takaai,Takashi Washio,Shinobu Takizawa,Hiroaki Sasai +9 more
TL;DR: A highly atom-economical enantioselective organocatalyzed Rauhut-Currier and [3+2] annulation sequence has been established by using a flow system and functionalized chiral spirooxindole analogues were obtained in high yield.
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Pd(II)-SDP-catalyzed enantioselective 5-exo-dig cyclization of γ-alkynoic acids: application to the synthesis of functionalized dihydofuran-2(3H)-ones containing a chiral quaternary carbon center.
Vellaisamy Sridharan,Vellaisamy Sridharan,Lulu Fan,Shinobu Takizawa,Takeyuki Suzuki,Hiroaki Sasai +5 more
TL;DR: The Pd(II)-SDP-catalyzed first enantioselective intramolecular cyclization of α,α-disubstituted γ-alkynoic acids is described, afforded dihydrofuran-2(3H)-ones bearing a chiral quaternary carbon center in excellent yields with en antioselectivities up to 71%.
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Bifunctional Organocatalysts for Enantioselective aza-Morita-Baylis-Hillman (aza-MBH) Reactions
TL;DR: In this paper, chiral Bronsted acid units are connected with a Lewis base unit via a spacer, and the acid-base moieties act cooperatively as an enzyme-mimetic catalyst to activate substrates in the carbon-carbon bond forming reaction between a, α, β-unsaturated carbonyl compounds and N-tosylimines with high enantioselectivity.
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Synthetic Approach toward Antibiotic Tunicamycins. II.
TL;DR: In this article, the base-catalyzed addition of nitro sugar to sugar aldehyde yielded three isomeric dodecose derivatives, and their configurations have been studied.
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Synthetic Approach toward Antibiotic Tunicamycins. 3. Methyl 3,4,7,8-Tetra-O-acetyl-10-O-benzyl-2-benzyloxycarbonylamino-2,6-dideoxy-11,12-O-isopropylidene-β-L-dodecodialdo-(12R)-furanose-(12,9)-pyranosides-(1,5)
TL;DR: In this article, higher carbon carbohydrates, dodecose derivatives have been synthesized by the base-catalyzed addition of nitro sugar to sugar aldehyde, and the derivatives were then converted into corresponding hydroxy and acetoxy derivatives.