H
Hirohito Metoki
Researcher at Tohoku Pharmaceutical University
Publications - 326
Citations - 12676
Hirohito Metoki is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Blood pressure & Population. The author has an hindex of 47, co-authored 276 publications receiving 10877 citations. Previous affiliations of Hirohito Metoki include Japan Society for the Promotion of Science & Tohoku University.
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Journal ArticleDOI
CYP11B2 Polymorphisms and Home Blood Pressure in a Population-Based Cohort in Japanese: the Ohasama Study
Mitsunobu Matsubara,Tomomi Sato,Takuya Nishimura,Michiko Suzuki,Masahiro Kikuya,Hirohito Metoki,Mari Michimata,Ichiro Tsuji,Toshio Ogihara,Yutaka Imai +9 more
TL;DR: Two genetic polymorphisms, -344C/T and the gene conversion in intron 2, were investigated in association with home blood pressure (BP) values and clinical parameters in 1,242 subjects aged 40 and over in Ohasama, a rural Japanese community and demonstrated that the -344T allele was significantly associated with increased prevalence of hypertension.
Journal ArticleDOI
Plasma Fibrinogen, Ambulatory Blood Pressure, and Silent Cerebrovascular Lesions. The Ohasama Study
Yoko Aono,Takayoshi Ohkubo,Masahiro Kikuya,Azusa Hara,Takeo Kondo,Taku Obara,Hirohito Metoki,Ryusuke Inoue,Kei Asayama,Yoriko Shintani,Junichiro Hashimoto,Kazuhito Totsune,Haruhisa Hoshi,Hiroshi Satoh,Shin-ichi Izumi,Yutaka Imai +15 more
TL;DR: The 24-hour ABP and plasma fibrinogen levels were closely and independently associated with the risk of silent cerebrovascular lesions including white matter hyperintensity and lacunar infarct.
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Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home
Keiko Hosohata,Masahiro Kikuya,Takayoshi Ohkubo,Hirohito Metoki,Kei Asayama,Ryusuke Inoue,Taku Obara,Junichiro Hashimoto,Kazuhito Totsune,Haruhisa Hoshi,Hiroshi Satoh,Yutaka Imai +11 more
TL;DR: The reproducibility of single nocturnal blood pressure during sleep as measured using a self-measurement device at home was not good, especially for subjects who experienced different quality of sleep in each session.
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Use of 2003 European Society of Hypertension-European Society of Cardiology guidelines for predicting stroke using self-measured blood pressure at home: the Ohasama study.
Kei Asayama,Takayoshi Ohkubo,Masahiro Kikuya,Hirohito Metoki,Taku Obara,Haruhisa Hoshi,Junichiro Hashimoto,Kazuhito Totsune,Hiroshi Satoh,Yutaka Imai +9 more
TL;DR: The risk stratification system proposed in the 2003 ESH-ESC guidelines is valid for the prediction of stroke in this Japanese study population, and has a stronger predictive power when based on HBP than on CBP.
Journal ArticleDOI
Serum magnesium, ambulatory blood pressure, and carotid artery alteration: the Ohasama study.
Takanao Hashimoto,Azusa Hara,Takayoshi Ohkubo,Masahiro Kikuya,Yoriko Shintani,Hirohito Metoki,Ryusuke Inoue,Kei Asayama,Atsuhiro Kanno,Manami Nakashita,Shiho Terata,Taku Obara,Takuo Hirose,Haruhisa Hoshi,Kazuhito Totsune,Kazuhito Totsune,Hiroshi Satoh,Yutaka Imai +17 more
TL;DR: Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration and further investigations are needed to examine the relationship between sMG levels and the incidence of cardiovascular disease.