H
Hiroki Otani
Researcher at Shimane University
Publications - 106
Citations - 16954
Hiroki Otani is an academic researcher from Shimane University. The author has contributed to research in topics: Receptor & Fetus. The author has an hindex of 31, co-authored 103 publications receiving 12126 citations. Previous affiliations of Hiroki Otani include Kobe University.
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Journal ArticleDOI
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Michiru Nishita,Seung-Yeol Park,Tadashi Nishio,Koki Kamizaki,ZhiChao Wang,Kota Tamada,Toru Takumi,Ryuju Hashimoto,Hiroki Otani,Gregory J. Pazour,Victor W. Hsu,Yasuhiro Minami +11 more
TL;DR: It is found that intraflagellar transport 20 mediates the ability of Ror2 signaling to induce the invasiveness of tumors that lack primary cilia, and IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex.
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Cardiac fibrosis in mice lacking brain natriuretic peptide
Naohisa Tamura,Yoshihiro Ogawa,Hideki Chusho,Kenji Nakamura,Kazuki Nakao,Michio Suda,Masato Kasahara,Ryuju Hashimoto,Goro Katsuura,Masashi Mukoyama,Hiroshi Itoh,Yoshihiko Saito,Issei Tanaka,Hiroki Otani,Motoya Katsuki,Kazuwa Nakao +15 more
TL;DR: This study establishes BNP as a cardiomyocyte-derived antifibrotic factor in vivo and provides evidence for its role as a local regulator of ventricular remodeling.
Journal ArticleDOI
Rac1 is required for the formation of three germ layers during gastrulation.
Kazuhiro Sugihara,Norio Nakatsuji,Kenji Nakamura,Kazuki Nakao,Ryuju Hashimoto,Hiroki Otani,Hiroyuki Sakagami,Hisatake Kondo,Shiro Nozawa,Atsu Aiba,Motoya Katsuki +10 more
TL;DR: Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo.
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Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
Shigeto Takeuchi,Kiyoshi Takeda,Isao Oishi,Masashi Nomi,Makoto Ikeya,Kyoko Itoh,Shingo Tamura,Takahiro Ueda,Toshihisa Hatta,Hiroki Otani,Toshio Terashima,Shinji Takada,Hirohei Yamamura,Shizuo Akira,Yasuhiro Minami +14 more
TL;DR: A mouse receptor tyrosine kinase (RTK), mRor2, which belongs to the Ror‐family of RTKs consisting of at least two structurally related members, is primarily expressed in the heart and nervous system during mouse development.
Journal ArticleDOI
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
Hajime Kanda,Yoshikazu Tamori,Hiroaki Shinoda,Mari Yoshikawa,Motoyoshi Sakaue,Jun Udagawa,Hiroki Otani,Fumi Tashiro,Jun-ichi Miyazaki,Masato Kasuga +9 more
TL;DR: Munc18c inhibits insulin-stimulated externalization of GLUT4 in a wortmannin-sensitive manner and disruption of the interaction between syntaxin4 and Munc18c in adipocytes might result in enhancement of insulin- StimulatedGLUT4 externalization.