R
Ryuju Hashimoto
Researcher at Shimane University
Publications - 44
Citations - 15243
Ryuju Hashimoto is an academic researcher from Shimane University. The author has contributed to research in topics: Leptin & Receptor tyrosine kinase. The author has an hindex of 18, co-authored 44 publications receiving 10537 citations.
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Journal ArticleDOI
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Michiru Nishita,Seung-Yeol Park,Tadashi Nishio,Koki Kamizaki,ZhiChao Wang,Kota Tamada,Toru Takumi,Ryuju Hashimoto,Hiroki Otani,Gregory J. Pazour,Victor W. Hsu,Yasuhiro Minami +11 more
TL;DR: It is found that intraflagellar transport 20 mediates the ability of Ror2 signaling to induce the invasiveness of tumors that lack primary cilia, and IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex.
Journal ArticleDOI
Cardiac fibrosis in mice lacking brain natriuretic peptide
Naohisa Tamura,Yoshihiro Ogawa,Hideki Chusho,Kenji Nakamura,Kazuki Nakao,Michio Suda,Masato Kasahara,Ryuju Hashimoto,Goro Katsuura,Masashi Mukoyama,Hiroshi Itoh,Yoshihiko Saito,Issei Tanaka,Hiroki Otani,Motoya Katsuki,Kazuwa Nakao +15 more
TL;DR: This study establishes BNP as a cardiomyocyte-derived antifibrotic factor in vivo and provides evidence for its role as a local regulator of ventricular remodeling.
Journal ArticleDOI
Rac1 is required for the formation of three germ layers during gastrulation.
Kazuhiro Sugihara,Norio Nakatsuji,Kenji Nakamura,Kazuki Nakao,Ryuju Hashimoto,Hiroki Otani,Hiroyuki Sakagami,Hisatake Kondo,Shiro Nozawa,Atsu Aiba,Motoya Katsuki +10 more
TL;DR: Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo.
Journal ArticleDOI
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Isao Oishi,Shigeto Takeuchi,Ryuju Hashimoto,Akira Nagabukuro,Takahiro Ueda,Zhao Jun Liu,Toshihisa Hatta,Shizuo Akira,Yoichi Matsuda,Hirohei Yamamura,Hiroki Otani,Yasuhiro Minami +11 more
TL;DR: Drosophila neurospecific receptor tyrosine kinases, Dror and Dnrk, as well as Ror1 and Ror2 RTKs, isolated from human neuroblastoma, have been identified as a structurally related novel family ofRTKs (Ror‐family RTKS).
Journal ArticleDOI
The Role of Leptin in the Development of the Cerebral Cortex in Mouse Embryos
Jun Udagawa,Ryuju Hashimoto,Hiroaki Suzuki,Toshihisa Hatta,Yusuke Sotomaru,Kyoji Hioki,Yukiko Kagohashi,Yukiko Kagohashi,Tatsuji Nomura,Yasuhiro Minami,Hiroki Otani +10 more
TL;DR: The results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos.