H
Hiromi Mochizuki
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 9
Citations - 600
Hiromi Mochizuki is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Induced pluripotent stem cell & Somatic cell. The author has an hindex of 5, co-authored 9 publications receiving 564 citations.
Papers
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Journal ArticleDOI
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
Momoko Maekawa,Kei Yamaguchi,Tomonori Nakamura,Ran Shibukawa,Ikumi Kodanaka,Tomoko Ichisaka,Yoshifumi Kawamura,Hiromi Mochizuki,Naoki Goshima,Shinya Yamanaka +9 more
TL;DR: DNA microarray analyses show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation, including Myc, Nanog, Lin28, Wnt, Essrb and the mesenchymal–epithelial transition.
Patent
Method of efficiently establishing induced pluripotent stem cells
TL;DR: In this article, a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28 B to a somatic cell, particularly to a soma cell on which Lin28 is ineffective or less effective than Lin28b in improving the establishment efficiency of iPS cells.
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Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.
Ayano Doi,Kosuke Ishikawa,Nao Shibata,Emi Ito,Jiro Fujimoto,Mizuki Yamamoto,Hatsuki Shiga,Hiromi Mochizuki,Yoshifumi Kawamura,Naoki Goshima,Kentaro Semba,Kentaro Semba,Shinya Watanabe +12 more
TL;DR: It is found that overexpression of retinoic acid receptor α (RARA) disrupted normal acinar structure and induced epithelial‐to‐mesenchymal transition (EMT) and the mRNA levels of known EMT‐inducing factors, including SLUG, FOXC2, ZEB1, and ZEB2, were significantly increased upon RARA overeexpression.
Journal ArticleDOI
Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.
Makoto Saito,Yukiko Kato,Emi Ito,Jiro Fujimoto,Kosuke Ishikawa,Ayano Doi,Kentaro Kumazawa,Atsuka Matsui,Shiori Takebe,Takaomi Ishida,Sakura Azuma,Hiromi Mochizuki,Yoshifumi Kawamura,Yuka Yanagisawa,Reiko Honma,Jun-ichi Imai,Hirokazu Ohbayashi,Naoki Goshima,Kentaro Semba,Shinya Watanabe +19 more
TL;DR: An integrated analysis system of amplicons is established using retrovirus‐mediated gene transfer coupled with a human full‐length cDNA set, and GRB7 is identified as a context‐dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ER BB2 and Akt.
Journal ArticleDOI
Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells.
Tsutomu Motohashi,Natsuki Watanabe,Masahiro Nishioka,Yuhki Nakatake,Piao Yulan,Hiromi Mochizuki,Yoshifumi Kawamura,Minoru S.H. Ko,Minoru S.H. Ko,Naoki Goshima,Takahiro Kunisada +10 more
TL;DR: The gene expression profile of a pure NC subpopulation isolated from Sox10-IRES-Venus mice was analyzed and it was suggested that SOX10 and SOX9 are the key factors necessary for the direct conversion of MEFs into NC cells.