R
Ran Shibukawa
Researcher at International Practical Shooting Confederation
Publications - 15
Citations - 453
Ran Shibukawa is an academic researcher from International Practical Shooting Confederation. The author has contributed to research in topics: Induced pluripotent stem cell & SOX2. The author has an hindex of 4, co-authored 14 publications receiving 401 citations. Previous affiliations of Ran Shibukawa include Kyoto University.
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Journal ArticleDOI
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
Momoko Maekawa,Kei Yamaguchi,Tomonori Nakamura,Ran Shibukawa,Ikumi Kodanaka,Tomoko Ichisaka,Yoshifumi Kawamura,Hiromi Mochizuki,Naoki Goshima,Shinya Yamanaka +9 more
TL;DR: DNA microarray analyses show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation, including Myc, Nanog, Lin28, Wnt, Essrb and the mesenchymal–epithelial transition.
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Modeling Drug-Induced Neuropathy Using Human iPSCs for Predictive Toxicology.
R. Ohara,R. Ohara,Keiko Imamura,F. Morii,F. Morii,Naohiro Egawa,Kayoko Tsukita,Takako Enami,Ran Shibukawa,Toshiki Mizuno,Masanori Nakagawa,Haruhisa Inoue +11 more
TL;DR: It is shown that treatment with drugs known to cause neuropathy caused mitochondrial aggregations in neurites with adenosine triphosphate shortage in both CMT and control neurons, although more severely in CMT.
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iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility.
Keiko Imamura,Keiko Imamura,Yasuteru Sakurai,Takako Enami,Ran Shibukawa,Ran Shibukawa,Yohei Nishi,Akira Ohta,Tsugumine Shu,Jitsutaro Kawaguchi,Sayaka Okada,Thomas Hoenen,Jiro Yasuda,Haruhisa Inoue,Haruhisa Inoue +14 more
TL;DR: In this paper, a screen of repurposed drugs using Sendai virus (an RNA virus of the family Paramyxoviridae), with human-induced pluripotent stem cells (iPSCs) to explore existing drugs that may present anti-RNA viral activity was conducted.
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Analysis of neural crest cells from Charcot-Marie-Tooth disease patients demonstrates disease-relevant molecular signature.
Fukiko Kitani-Morii,Keiko Imamura,Takayuki Kondo,Ryo Ohara,Takako Enami,Ran Shibukawa,Takuya Yamamoto,Kazuya Sekiguchi,Junya Toguchida,Toshiki Mizuno,Masanori Nakagawa,Haruhisa Inoue +11 more
TL;DR: It is suggested that patient-iPSC-derived neural crest cells could be a cellular model for investigating genetically heterogeneous disease CMT and might provide a therapeutic target for the disease.
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Induced pluripotent stem cells derived from a patient with familial idiopathic basal ganglia calcification (IBGC) caused by a mutation in SLC20A2 gene
Shin-ichiro Sekine,Takayuki Kondo,Nagahisa Murakami,Keiko Imamura,Takako Enami,Ran Shibukawa,Kayoko Tsukita,Misato Funayama,Masatoshi Inden,Hisaka Kurita,Isao Hozumi,Haruhisa Inoue +11 more
TL;DR: The established IBGC-iPSCs showed typical iPSC morphology, pluripotency markers, normal karyotype, and the ability of in vitro differentiation into three-germ layers, which will be useful for further elucidating the pathomechanism and/or drug development for IBGC.