S
Shinya Watanabe
Researcher at Fukushima Medical University
Publications - 86
Citations - 5711
Shinya Watanabe is an academic researcher from Fukushima Medical University. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 21, co-authored 80 publications receiving 5366 citations. Previous affiliations of Shinya Watanabe include Tokyo Medical and Dental University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Tetsu Akiyama,J Ishida,Shinsaku Nakagawa,Hiroshi Ogawara,Shinya Watanabe,N Itoh,M Shibuya,Yasuo Fukami +7 more
TL;DR: Genistein inhibited the EGF-stimulated increase in phosphotyrosine level in A431 cells and scarcely inhibited the enzyme activities of serine- and threonine-specific protein kinases such as cAMP-dependent protein kinase, phosphorylase kinases, and the Ca2+/phospholipid-dependent enzymeprotein kinase C.
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Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Naoki Goshima,Yoshifumi Kawamura,Akiko Fukumoto,Aya Miura,Reiko Honma,Ryohei Satoh,Ai Wakamatsu,Ai Wakamatsu,Junichi Yamamoto,Kouichi Kimura,Tetsuo Nishikawa,Taichi Andoh,Yuki Iida,Kumiko Ishikawa,Emi Ito,Naoko Kagawa,Chie Kaminaga,Keiichi Kanehori,Bunsei Kawakami,Kiyokazu Kenmochi,Rie Kimura,Miki Kobayashi,Toshihiro Kuroita,Hisashi Kuwayama,Yukio Maruyama,Kiyoshi Matsuo,Kazuyoshi Minami,Mariko Mitsubori,Masatoshi Mori,Riyo Morishita,Atsushi Murase,Akira Nishikawa,Shigemichi Nishikawa,Toshihiko Okamoto,Noriko Sakagami,Yutaka Sakamoto,Yukari Sasaki,Tomoe Seki,Saki Sono,Akio Sugiyama,Tsuyoshi Sumiya,Tomoko Takayama,Yukiko Takayama,Hiroyuki Takeda,Takushi Togashi,Kazuhide Yahata,Hiroko Yamada,Yuka Yanagisawa,Yaeta Endo,Fumio Imamoto,Yasutomo Kisu,Shigeo Tanaka,Takao Isogai,Jun-ichi Imai,Shinya Watanabe,Nobuo Nomura +55 more
TL;DR: A foundation for simple and efficient production of human proteins using the versatile Gateway vector system is prepared and several cytokines containing disulfide bonds were produced in an active form in a nonreducing wheat germ cell-free expression system.
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NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells
Noritaka Yamaguchi,Tetsunari Oyama,Emi Ito,Hitoshi Satoh,Sakura Azuma,Mitsuhiro Hayashi,Ken Shimizu,Reiko Honma,Yuka Yanagisawa,Akira Nishikawa,Mika Kawamura,Jun-ichi Imai,Jun-ichi Imai,Susumu Ohwada,Kuniaki Tatsuta,Jun-ichiro Inoue,Kentaro Semba,Shinya Watanabe,Shinya Watanabe +18 more
TL;DR: Findings indicate that NOTCH3-mediated signaling rather than NOTCH1- mediated signaling plays an important role in the proliferation of ErbB2-negative breast tumor cells and that targeted suppression of this signaling pathway may be a promising strategy for the treatment of Er bBB 2- negative breast cancers.
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CD24 is expressed specifically in the nucleus pulposus of intervertebral discs.
Nobuyuki Fujita,Takeshi Miyamoto,Jun-ichi Imai,Naobumi Hosogane,Toru Suzuki,Mitsuru Yagi,Kozo Morita,Ken Ninomiya,Kana Miyamoto,Hironari Takaishi,Morio Matsumoto,Hideo Morioka,Hiroo Yabe,Kazuhiro Chiba,Shinya Watanabe,Yoshiaki Toyama,Toshio Suda +16 more
TL;DR: CD24, a glycosylphosphatidylinositol anchor protein, was identified as a cell surface marker for NP and was detected in the herniated NP and chordoma, a malignant primary tumor derived from notochordal cells, while it was absent in chondrosarcoma.
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Constitutive activation of nuclear factor-κB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines
Noritaka Yamaguchi,Taku Ito,Sakura Azuma,Emi Ito,Reiko Honma,Yuka Yanagisawa,Akira Nishikawa,Mika Kawamura,Jun-ichi Imai,Shinya Watanabe,Kentaro Semba,Jun-ichiro Inoue +11 more
TL;DR: Results suggest that constitutive NF‐κB activation, partially dependent on NIK, is preferentially involved in proliferation of basal‐like subtype breast cancer cells and may be a useful therapeutic target for this subtype of cancer.