H
Hirosato Tanaka
Researcher at Niigata University
Publications - 50
Citations - 3115
Hirosato Tanaka is an academic researcher from Niigata University. The author has contributed to research in topics: Bacillus circulans & Glucanase. The author has an hindex of 20, co-authored 50 publications receiving 3022 citations.
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Journal ArticleDOI
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.
Kazuhiro Sanpei,Hiroki Takano,Shuichi Igarashi,Tomoe Sato,Mutsuo Oyake,Hidenao Sasaki,Akemi Wakisaka,Kunio Tashiro,Y Ishida,Takeshi Ikeuchi,Reiji Koide,Masaaki Saito,Aki Sato,Toshihisa Tanaka,S Hanyu,Yoshihisa Takiyama,Masatoyo Nishizawa,N Shimizu,Yoshiko Nomura,Masaya Segawa,Kiyoshi Iwabuchi,I. Eguchi,Hirosato Tanaka,Hitoshi Takahashi,Shoji Tsuji +24 more
TL;DR: A novel strategy, the direct identification of repeat expansion and cloning technique (DIRECT), which allows selective detection of expanded GAG repeats and cloning of the genes involved and will dramatically accelerate the search for causative genes of neuropsychiatric diseases caused by trinucleotide repeat expansions.
Journal Article
Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27
Hiroto Matsumine,Masaaki Saito,Satoe Shimoda-Matsubayashi,Hirosato Tanaka,A. Ishikawa,Y. Nakagawa-Hattori,M. Yokochi,T Kobayashi,Shuichi Igarashi,Hiroki Takano,Kazuhiro Sanpei,R Koike,H Mori,T Kondo,Y Mizutani,Alejandro A. Schäffer,Yasuhiro Yamamura,Shigenobu Nakamura,Shigeki Kuzuhara,Shoji Tsuji,Yoshikuni Mizuno +20 more
TL;DR: Strong evidence is discovered for the localization of the AR-JP gene at chromosome 6q25, including the SOD2 locus, by linkage analysis of diallelic polymorphism of the Mn-superoxide dismutase gene (SOD2).
Journal ArticleDOI
The roles of the C-terminal domain and type III domains of chitinase A1 from Bacillus circulans WL-12 in chitin degradation.
TL;DR: The mature form of chitinase A1 from Bacillus circulans WL-12 comprises a C-terminal domain, two type III modules (domains), and a large N-Terminal domain which contains the catalytic site of the enzyme.
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Close Associations between Prevalences of Dominantly Inherited Spinocerebellar Ataxias with CAG-Repeat Expansions and Frequencies of Large Normal CAG Alleles in Japanese and Caucasian Populations
Hiroki Takano,Géraldine Cancel,Takeshi Ikeuchi,Diego Lorenzetti,R. Mawad,Giovanni Stevanin,Olivier Didierjean,Alexandra Durr,Mutsuo Oyake,Takayoshi Shimohata,R. Sasaki,Reiji Koide,Shuichi Igarashi,Shigenobu Hayashi,Yoshihisa Takiyama,Masatoyo Nishizawa,Hirosato Tanaka,Huda Y. Zoghbi,Alexis Brice,Shoji Tsuji +19 more
TL;DR: The hypothesis that the frequencies of normal alleles (ANs) with a relatively large number of CAG repeats (large ANs) are related to the prevalences of the dominant spinocerebellar ataxias (SCAs) is tested and the assumption that large ANs contribute to generation of expanded allels (AEs) is supported.
Journal ArticleDOI
Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease
Yoshihisa Takiyama,Shuichi Igarashi,Ekaterina Rogaeva,Kotaro Endo,Evgeny I. Rogaev,Hirosato Tanaka,R. Sherrington,Kazuhiro Sanpei,Yan Liang,Masaaki Saito +9 more
TL;DR: The disease phenotype is significantly more severe and had an early age of onset (16 years), which suggests that the expanded allele in the MJD1 gene could exert its effect either by a dominant negative effect (putatively excluded in HD) or by a gain of function effect as proposed for HD.