H
Hiroshi Nakanishi
Researcher at Saint Louis University
Publications - 23
Citations - 1122
Hiroshi Nakanishi is an academic researcher from Saint Louis University. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 14, co-authored 21 publications receiving 1029 citations. Previous affiliations of Hiroshi Nakanishi include University of Tokyo & Ohio State University.
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Journal ArticleDOI
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.
Shu Okamura,Hirofumi Arakawa,Tomoaki Tanaka,Hiroshi Nakanishi,Ching Ching Ng,Yoichi Taya,Morito Monden,Yusuke Nakamura +7 more
TL;DR: The results suggest that p53DINP1 may regulate p53-dependent apoptosis through phosphorylation of p53 at Ser46, serving as a cofactor for the putative p 53-Ser46 kinase.
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Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
Taewan Kim,Ri Cui,Ri Cui,Young-Jun Jeon,Ji Hoon Lee,Ju Hee Lee,Hosung Sim,Jong Kook Park,Paolo Fadda,Esmerina Tili,Hiroshi Nakanishi,Man Il Huh,Sung Hak Kim,Sung Hak Kim,Ju Hwan Cho,Bong Hwan Sung,Yong Peng,Tae Jin Lee,Zhenghua Luo,Hui-Lung Sun,Huijun Wei,Hansjuerg Alder,Jeong Su Oh,Kang Sup Shim,Sang Bong Ko,Carlo M. Croce +25 more
TL;DR: Interestingly, it is found that the cancer-associated variant rs6983267 regulating the enhancer activity is significantly associated with the expression of one of the lncRNAs CARLo-5 and that CAR Lo-5 has an oncogenic function.
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MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma
Wei Meng,Zhenqing Ye,Ri Cui,Ri Cui,James Perry,Vaia Dedousi-Huebner,Alexander Huebner,Yao Wang,Bin Li,Stefano Volinia,Hiroshi Nakanishi,Taewan Kim,Sung Suk Suh,Leona W. Ayers,Patrick Ross,Carlo M. Croce,Arnab Chakravarti,Victor X. Jin,Tim Lautenschlaeger +18 more
TL;DR: In vitro functional assays showed that miR-31 increases cell migration, invasion, and proliferation in an ERK1/2 signaling-dependent manner and potentially identified a miRNA predicting the presence of lymph node metastasis and survival outcomes in patients of lung adenocarcinoma.
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ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias
TL;DR: Whether ALL1 fusion proteins are involved in regulation of Eph/ephrin genes is sought and apoptotic cell death is shown, specific for leukemic cells carrying the t(4;11) chromosome translocation, after treatment of the cells with an ERK phosphorylation blocker.
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Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway
Hiroshi Nakanishi,Cristian Taccioli,Cristian Taccioli,Jeff Palatini,Cecilia Fernandez-Cymering,Ri Cui,Taewan Kim,Stefano Volinia,Carlo M. Croce +8 more
TL;DR: It is reported that miR-125b-1 causes mitogen-activated protein kinase pathway dysfunction through regulation of TACSTD2 expression, which may have a key role in the pathogenesis and progression of squamous cell carcinomas of head and neck and possibly of other tumors.