S
Sung Suk Suh
Researcher at Ohio State University
Publications - 19
Citations - 1866
Sung Suk Suh is an academic researcher from Ohio State University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 9 publications receiving 1733 citations. Previous affiliations of Sung Suk Suh include Hebrew University of Jerusalem & Korean Ocean Research and Development Institute.
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Journal ArticleDOI
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis
Flavia Pichiorri,Sung Suk Suh,Marco Ladetto,Michael Kuehl,Tiziana Palumbo,Daniela Drandi,Cristian Taccioli,Nicola Zanesi,Hansjuerg Alder,John P. Hagan,Reinhold Munker,Stefano Volinia,Mario Boccadoro,Ramiro Garzon,Antonio Palumbo,Rami I. Aqeilan,Rami I. Aqeilan,Carlo M. Croce +17 more
TL;DR: A MM miRNA signature is described, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis that were shown to down regulate expression of SOCS-1 and miR-19a and 19b.
Journal ArticleDOI
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Taewan Kim,Angelo Veronese,Flavia Pichiorri,Tae Jin Lee,Young-Jun Jeon,Stefano Volinia,Pascal Pineau,Agnès Marchio,Jeff Palatini,Sung Suk Suh,Hansjuerg Alder,Chang Gong Liu,Anne Dejean,Carlo M. Croce +13 more
TL;DR: By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.
Journal ArticleDOI
Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development
Flavia Pichiorri,Flavia Pichiorri,Sung Suk Suh,Sung Suk Suh,Alberto Rocci,Luciana De Luca,Cristian Taccioli,Cristian Taccioli,Ramasamy Santhanam,Wenchao Zhou,Don M. Benson,Craig Hofmainster,Hansjuerg Alder,Michela Garofalo,Gianpiero Di Leva,Stefano Volinia,Stefano Volinia,Huey Jen Lin,Danilo Perrotti,Michael Kuehl,Rami I. Aqeilan,Rami I. Aqeilan,Antonio Palumbo,Carlo M. Croce +23 more
TL;DR: Evidence is provided that miR-192, 194, and 215, which are downregulated in a subset of newly diagnosed MMs, can be transcriptionally activated by p53 and then modulate MDM2 expression, and that their downregulation plays a key role in MM development.
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MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme
Sung Suk Suh,Ji Young Yoo,Gerard J. Nuovo,Young-Jun Jeon,Seokho Kim,Tae Jin Lee,Taewan Kim,Arianna Bakac̀s,Hansjuerg Alder,Balveen Kaur,Rami I. Aqeilan,Rami I. Aqeilan,Flavia Pichiorri,Carlo M. Croce +13 more
TL;DR: There is a recurrent autoregulatory circuit involving expression of p53, E2F1, and MYC to regulate the expression of miR-25 and -32, which are miRNAs that, in turn, control p53 accumulation.
Journal ArticleDOI
MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma
Wei Meng,Zhenqing Ye,Ri Cui,Ri Cui,James Perry,Vaia Dedousi-Huebner,Alexander Huebner,Yao Wang,Bin Li,Stefano Volinia,Hiroshi Nakanishi,Taewan Kim,Sung Suk Suh,Leona W. Ayers,Patrick Ross,Carlo M. Croce,Arnab Chakravarti,Victor X. Jin,Tim Lautenschlaeger +18 more
TL;DR: In vitro functional assays showed that miR-31 increases cell migration, invasion, and proliferation in an ERK1/2 signaling-dependent manner and potentially identified a miRNA predicting the presence of lymph node metastasis and survival outcomes in patients of lung adenocarcinoma.