T
Tatsuya Nakamura
Researcher at Ohio State University
Publications - 39
Citations - 5488
Tatsuya Nakamura is an academic researcher from Ohio State University. The author has contributed to research in topics: Gene & Fusion protein. The author has an hindex of 28, co-authored 37 publications receiving 5268 citations. Previous affiliations of Tatsuya Nakamura include Thomas Jefferson University & University of Ferrara.
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Journal ArticleDOI
ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation
Tatsuya Nakamura,Toshiki Mori,Shinichiro Tada,Wladyslaw A. Krajewski,Tanya Rozovskaia,Richard Wassell,Garrett C. Dubois,Alexander Mazo,Carlo M. Croce,Eli Canaani +9 more
TL;DR: Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL- 1-dependent Hox a9 gene, and histones H3 and H4 are acetylated at this promoter.
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MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Ramiro Garzon,Stefano Volinia,Stefano Volinia,Chang Gong Liu,Cecilia Fernandez-Cymering,Tiziana Palumbo,Flavia Pichiorri,Muller Fabbri,Kevin R. Coombes,Hansjuerg Alder,Tatsuya Nakamura,Neal Flomenberg,Guido Marcucci,George A. Calin,Steven M. Kornblau,Hagop M. Kantarjian,Clara D. Bloomfield,Michael Andreeff,Carlo M. Croce +18 more
TL;DR: It is concluded that miRNA expression in AML is closely associated with cytogenetics and FLT3-ITD mutations, and a small subset of miRNAs is correlated with survival.
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Knockdown of ALR (MLL2) Reveals ALR Target Genes and Leads to Alterations in Cell Adhesion and Growth
Irina Issaeva,Yulia Zonis,Tanya Rozovskaia,Kira Orlovsky,Carlo M. Croce,Tatsuya Nakamura,Alexander Mazo,Lea Eisenbach,Eli Canaani +8 more
TL;DR: The results suggest that ALR is a transcriptional activator that induces the transcription of target genes by covalent histone modification, which appears to be involved in the regulation of adhesion-related cytoskeletal events, which might affect cell growth and survival.
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Global and Hox-specific roles for the MLL1 methyltransferase.
Matthew G. Guenther,Richard G. Jenner,Brett Chevalier,Tatsuya Nakamura,Carlo M. Croce,Eli Canaani,Richard A. Young +6 more
TL;DR: The ability of MLL1 to serve as a start site-specific global transcriptional regulator and to participate in larger chromatin domains at the Hox genes reveals dual roles for M LL1 in maintenance of cellular identity.
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MicroRNA Cluster 221-222 and Estrogen Receptor α Interactions in Breast Cancer
Gianpiero Di Leva,Pierluigi Gasparini,Claudia Piovan,Apollinaire Ngankeu,Michela Garofalo,Cristian Taccioli,Marilena V. Iorio,Meng Li,Stefano Volinia,Hansjuerg Alder,Tatsuya Nakamura,Gerard J. Nuovo,Yunlong Liu,Kenneth P. Nephew,Carlo M. Croce +14 more
TL;DR: The findings suggest that the negative regulatory loop involving miR-221-222 and ERalpha may confer proliferative advantage and migratory activity to breast cancer cells and promote the transition from ER-positive to ER-negative tumors.