H
Hiroshi Sakai
Researcher at Pasteur Institute
Publications - 143
Citations - 2460
Hiroshi Sakai is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Gene & DNA replication. The author has an hindex of 26, co-authored 141 publications receiving 2172 citations. Previous affiliations of Hiroshi Sakai include Centre national de la recherche scientifique & Tokyo Institute of Technology.
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Journal ArticleDOI
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations
Lorenzo Giordani,Gary J. He,Elisa Negroni,Hiroshi Sakai,Justin Y. C. Law,M. Mona Siu,Raymond Wan,Aurélien Corneau,Shahragim Tajbakhsh,Tom H. Cheung,Fabien Le Grand +10 more
TL;DR: Ten different mononuclear cell types in adult mouse muscle are mapped using a combined approach of single-cell RNA sequencing and mass cytometry to yield crucial insights into muscle-resident cell-type identities and can be exploited to study muscle diseases.
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Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle
Aurélie Chiche,Aurélie Chiche,Isabelle Roux,Mathieu von Joest,Mathieu von Joest,Hiroshi Sakai,Hiroshi Sakai,Sabela Búa Aguín,Sabela Búa Aguín,Coralie Cazin,Coralie Cazin,Rana Salam,Laurence Fiette,Olinda Alegria,Olinda Alegria,Patricia Flamant,Shahragim Tajbakhsh,Shahragim Tajbakhsh,Han Li,Han Li +19 more
TL;DR: It is shown that acute and chronic injury enables transcription-factor-mediated reprogramming in skeletal muscle and this response frequently originates from Pax7+ muscle stem cells, highlighting a beneficial paracrine effect of injury-induced senescence on cellular plasticity.
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Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation
Lenka Skalska,Robert Stojnic,Jinghua Li,Bettina Fischer,Gustavo Cerda-Moya,Hiroshi Sakai,Shahragim Tajbakhsh,Steven Russell,Boris Adryan,Sarah J. Bray +9 more
TL;DR: While many histone modifications were unchanged by Su(H) binding or Notch activation, rapid changes in acetylation of H3K56 at Notch‐regulated enhancers appear to be a conserved indicator of enhancer activation.
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In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells
Hidetoshi Sakurai,Yasuko Sakaguchi,Emi Shoji,Tokiko Nishino,Izumi Maki,Hiroshi Sakai,Kazunori Hanaoka,Akira Kakizuka,Atsuko Sehara-Fujisawa +8 more
TL;DR: A protocol for the differentiation of mouse iPS cells into paraxial mesodermal lineages in serum-free culture was established and exhibited differentiation potential into osteogenic, chondrogenic, and myogenic cells both in vitro and in vivo and contributed to muscle regeneration.
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Mossbauer Spectroscopic Study of Iodine-Doped Polyacetylene
TL;DR: In this article, the Mossbauer spectroscopy has been applied to iodine-doped polyacetylene employing 129 I. It is found that the polymer films contain I -, I 3 - and I 5 - with symmetrical charge population, where the content of each iodide anion depends on the doping level.