H
Hiroyuki Nakanishi
Researcher at Osaka University
Publications - 246
Citations - 11192
Hiroyuki Nakanishi is an academic researcher from Osaka University. The author has contributed to research in topics: Adherens junction & Hepatocellular carcinoma. The author has an hindex of 52, co-authored 216 publications receiving 10448 citations. Previous affiliations of Hiroyuki Nakanishi include Hiroshima University & National Institutes of Natural Sciences, Japan.
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Journal ArticleDOI
Nectin and afadin: novel organizers of intercellular junctions.
Yoshimi Takai,Hiroyuki Nakanishi +1 more
TL;DR: This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin- based tight junctions in epithelial cells and is furthermore involved in the formation of synapses in neurons and the organizations of heterotypic junctions between Sertoli cells and spermatids in the testis.
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Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.
Kenichi Takahashi,Hiroyuki Nakanishi,Masako Miyahara,Kenji Mandai,Keiko Satoh,Ayako Satoh,Hideo Nishioka,Junken Aoki,Akio Nomoto,Akira Mizoguchi,Yoshimi Takai +10 more
TL;DR: It is found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor–related protein (PRR) family consisting of PRR1 and -2, and has been identified recently to be the alphaherpes virus receptor.
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Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction
Kenji Mandai,Hiroyuki Nakanishi,Ayako Satoh,Hiroshi Obaishi,Manabu Wada,Hideo Nishioka,Masahiko Itoh,Akira Mizoguchi,Takeo Aoki,Toyoshi Fujimoto,Yoichi Matsuda,Shoichiro Tsukita,Yoshimi Takai +12 more
TL;DR: Results suggest that l-afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell AJ, and is likely to be a rat counterpart of human AF-6 protein.
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Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.
Akira Kishimoto,Kaoru Nishiyama,Hiroyuki Nakanishi,Yuko Uratsuji,H Nomura,Y Takeyama,Yasutomi Nishizuka +6 more
TL;DR: The substrate specificity of protein kinase C was studied and compared with that of cyclic AMP-dependent protein kinases by using bovine brain myelin basic protein as a model substrate to provide some clues to understanding the rationale that these kinases may show different but sometimes similar functions depending on the structure of target phosphate acceptor proteins.
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Rho as a regulator of the cytoskeleton
Yoshimi Takai,Yoshimi Takai,Takuya Sasaki,Takuya Sasaki,Kazuma Tanaka,Kazuma Tanaka,Hiroyuki Nakanishi,Hiroyuki Nakanishi +7 more
TL;DR: Evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.