H
Hisayoshi Hayashi
Researcher at University of Shizuoka
Publications - 59
Citations - 3024
Hisayoshi Hayashi is an academic researcher from University of Shizuoka. The author has contributed to research in topics: Intracellular pH & Paracellular transport. The author has an hindex of 20, co-authored 54 publications receiving 2660 citations. Previous affiliations of Hisayoshi Hayashi include University of Toronto.
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Journal ArticleDOI
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
Mirkka Koivusalo,Christopher Welch,Hisayoshi Hayashi,Cameron C. Scott,Moshe Kim,R. Todd Alexander,Nicolas Touret,Klaus M. Hahn,Sergio Grinstein +8 more
TL;DR: Inhibitors of Na+/H+ exchange proteins block macropinocytosis by lowering the pH near the plasma membrane, which in turn inhibits actin remodeling by Rho family GTPases.
Journal ArticleDOI
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
Shin-ichiro Karaki,Retsu Mitsui,Hisayoshi Hayashi,Ikuo Kato,Hiroshi Sugiya,Toshihiko Iwanaga,John B. Furness,Atsukazu Kuwahara +7 more
TL;DR: The results of the present study suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor, which is consistent with physiological data showing thatSCFAs stimulate the release of PYY and5-HT from the ileum and colon.
Journal ArticleDOI
Expression of the short-chain fatty acid receptor, GPR43, in the human colon.
Shin-ichiro Karaki,Hideaki Tazoe,Hisayoshi Hayashi,Hidefumi Kashiwabara,Kazunari Tooyama,Yuichi Suzuki,Atsukazu Kuwahara +6 more
TL;DR: The results indicate that the short chain fatty acid receptor, GPR43 is expressed by enteroendocrine L cells containing peptide YY in the human large intestine.
Journal ArticleDOI
Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine
Atsushi Tamura,Hisayoshi Hayashi,Mitsunobu Imasato,Yuji Yamazaki,Asuka Hagiwara,Masami Wada,Tetsuo Noda,Mitsuhiro Watanabe,Yuichi Suzuki,Sachiko Tsukita +9 more
TL;DR: It is proposed that the "Na(+))-leaky" claudin-15 is indispensable in vivo for the paracellular Na(+) permeability, luminal Na(+)-homeostasis, and efficient glucose absorption in the small intestine, but claud in-2 is indispensable for only the first of these functions.
Journal ArticleDOI
Megaintestine in Claudin-15–Deficient Mice
Atsushi Tamura,Yuka Kitano,Masaki Hata,Tatsuya Katsuno,Kazumasa Moriwaki,Hiroyuki Sasaki,Hisayoshi Hayashi,Yuichi Suzuki,Tetsuo Noda,Mikio Furuse,Shoichiro Tsukita,Sachiko Tsukita +11 more
TL;DR: It is proposed that claudin-15-based formation of TJs to organize the microenvironment including ion conductance is important for normal-sized morphogenesis of the small intestine.