H
Hisham Megahed
Publications - 4
Citations - 511
Hisham Megahed is an academic researcher. The author has contributed to research in topics: Exome & Internal medicine. The author has an hindex of 2, co-authored 4 publications receiving 443 citations.
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Journal ArticleDOI
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
Gaia Novarino,Ali G. Fenstermaker,Maha S. Zaki,Matan Hofree,Jennifer L. Silhavy,Andrew Heiberg,Mostafa Abdellateef,Basak Rosti,Eric Scott,Lobna Mansour,Amira Masri,Hülya Kayserili,Jumana Y. Al-Aama,Ghada M H Abdel-Salam,Ariana Karminejad,Majdi Kara,Bülent Kara,Bita Bozorgmehri,Tawfeg Ben-Omran,Faezeh Mojahedi,Iman G. Mahmoud,Naima Bouslam,Ahmed Bouhouche,Ali Benomar,Sylvain Hanein,Laure Raymond,Sylvie Forlani,Massimo Mascaro,Laila Selim,Nabil Shehata,Nasir A. S. Al-Allawi,Parayil Sankaran Bindu,Matloob Azam,Murat Gunel,Ahmet Okay Caglayan,Kaya Bilguvar,Aslıhan Tolun,Mahmoud Y. Issa,Jana Schroth,Emily Spencer,Rasim Ozgur Rosti,Naiara Akizu,Keith K. Vaux,Anide Johansen,Alice A. Koh,Hisham Megahed,Alexandra Durr,Alexis Brice,Giovanni Stevanin,S. Gabriel,Trey Ideker,Joseph G. Gleeson +51 more
TL;DR: Using whole-exome sequencing in combination with network analysis, 18 previously unknown putative HSP genes are identified and validated and link HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease.
Journal ArticleDOI
Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration.
Ashleigh E. Schaffer,Ashleigh E. Schaffer,Martin W. Breuss,Ahmet Okay Caglayan,Ahmet Okay Caglayan,Nouriya Al-Sanaa,Hind Y. Al-Abdulwahed,Hande Kaymakçalan,Cahide Yilmaz,Maha S. Zaki,Rasim Ozgur Rosti,Brett Copeland,Seung Tae Baek,Damir Musaev,Eric C. Scott,Tawfeg Ben-Omran,Ariana Kariminejad,Hülya Kayserili,Faezeh Mojahedi,Majdi Kara,Na Cai,Jennifer L. Silhavy,Seham Elsharif,Elif Fenercioglu,Bruce A. Barshop,Bülent Kara,Rengang Wang,Valentina Stanley,Kiely N. James,Rahul Nachnani,Aneesha Kalur,Hisham Megahed,Faruk Incecik,Sumita Danda,Yasemin Alanay,Eissa Faqeih,Gia Melikishvili,Lobna Mansour,Ian Miller,Biayna Sukhudyan,Jamel Chelly,William B. Dobyns,Kaya Bilguvar,Rami Abou Jamra,Murat Gunel,Joseph G. Gleeson +45 more
TL;DR: The findings identify CTNNA2 as the first catenin family member with biallelic mutations in humans, causing a new pachygyria syndrome linked to actin regulation, and uncover a key factor involved in ARP2/3 repression in neurons.
Journal ArticleDOI
Clinical and genetic characterization of ten Egyptian patients with Wolf-Hirschhorn syndrome and review of literature.
Mona K. Mekkawy,Alaa K. Kamel,Manal M. Thomas,Engy A. Ashaat,Maha S. Zaki,Ola M. Eid,Samira Ismail,Saida A Hammad,Hisham Megahed,Heba ElAwady,Khaled M Refaat,Shymaa Hussien,Nivine A. Helmy,Sally, G, Abd Allah,Amal M. Mohamed,Mona O. El Ruby +15 more
TL;DR: Wolf–Hirschhorn syndrome (WHS) is a multiple congenital anomalies/intellectual disability syndrome caused by partial loss of genetic material from the distal portion of the short arm of chromosome.
Journal ArticleDOI
Clinical Implications of S100A12 and Resolvin D1 Serum Levels, and Related Genes in Children with Familial Mediterranean Fever
Zeinab Y. Abdallah,Mona Ibrahim,Manal M. Thomas,Hisham Megahed,Ghada Nour Eldeen,Khaled H. Hamed,Mohamed Fares,Mahmoud ElHefnawi,Hala T. El-Bassyouni +8 more
TL;DR: In this paper, the role of S100A12 and resolvin D1-related genes and serum levels in the diagnosis and detection of subclinical inflammation in children with familial Mediterranean fever (FMF) during the quiescent stage of the disease was studied.