M
Mostafa Abdellateef
Researcher at University of California, San Diego
Publications - 4
Citations - 753
Mostafa Abdellateef is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cilium & Exome. The author has an hindex of 4, co-authored 4 publications receiving 648 citations. Previous affiliations of Mostafa Abdellateef include Howard Hughes Medical Institute.
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Journal ArticleDOI
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
Gaia Novarino,Ali G. Fenstermaker,Maha S. Zaki,Matan Hofree,Jennifer L. Silhavy,Andrew Heiberg,Mostafa Abdellateef,Basak Rosti,Eric Scott,Lobna Mansour,Amira Masri,Hülya Kayserili,Jumana Y. Al-Aama,Ghada M H Abdel-Salam,Ariana Karminejad,Majdi Kara,Bülent Kara,Bita Bozorgmehri,Tawfeg Ben-Omran,Faezeh Mojahedi,Iman G. Mahmoud,Naima Bouslam,Ahmed Bouhouche,Ali Benomar,Sylvain Hanein,Laure Raymond,Sylvie Forlani,Massimo Mascaro,Laila Selim,Nabil Shehata,Nasir A. S. Al-Allawi,Parayil Sankaran Bindu,Matloob Azam,Murat Gunel,Ahmet Okay Caglayan,Kaya Bilguvar,Aslıhan Tolun,Mahmoud Y. Issa,Jana Schroth,Emily Spencer,Rasim Ozgur Rosti,Naiara Akizu,Keith K. Vaux,Anide Johansen,Alice A. Koh,Hisham Megahed,Alexandra Durr,Alexis Brice,Giovanni Stevanin,S. Gabriel,Trey Ideker,Joseph G. Gleeson +51 more
TL;DR: Using whole-exome sequencing in combination with network analysis, 18 previously unknown putative HSP genes are identified and validated and link HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease.
Journal ArticleDOI
CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.
Ashleigh E. Schaffer,Veerle Rc Eggens,Ahmet Okay Caglayan,Miriam S. Reuter,Eric Scott,Nicole G. Coufal,Jennifer L. Silhavy,Yuanchao Xue,Hülya Kayserili,Katsuhito Yasuno,Rasim Ozgur Rosti,Mostafa Abdellateef,Caner Çağlar,Paul R. Kasher,J. Leonie Cazemier,Marian A. J. Weterman,Vincent Cantagrel,Vincent Cantagrel,Na Cai,Christiane Zweier,Umut Altunoglu,N. Bilge Satkin,Fesih Aktar,Beyhan Tüysüz,Cengiz Yalcinkaya,Hüseyin Çaksen,Kaya Bilguvar,Xiang-Dong Fu,Christopher R. Trotta,Stacey Gabriel,André Reis,Murat Gunel,Frank Baas,Joseph G. Gleeson +33 more
TL;DR: The data link tRNA maturation to neuronal development and neurodegeneration through defective CLP1 function in humans through impaired pre-tRNA cleavage.
Journal ArticleDOI
Mutations in CSPP1 Lead to Classical Joubert Syndrome
Naiara Akizu,Naiara Akizu,Jennifer L. Silhavy,Jennifer L. Silhavy,Rasim Ozgur Rosti,Rasim Ozgur Rosti,Eric Scott,Eric Scott,Ali G. Fenstermaker,Ali G. Fenstermaker,Jana Schroth,Jana Schroth,Maha S. Zaki,Henry Sanchez,Neerja Gupta,Madhulika Kabra,Majdi Kara,Tawfeg Ben-Omran,Basak Rosti,Basak Rosti,Alicia Guemez-Gamboa,Alicia Guemez-Gamboa,Emily Spencer,Emily Spencer,Roger Pan,Roger Pan,Na Cai,Na Cai,Mostafa Abdellateef,Mostafa Abdellateef,Stacey Gabriel,Jan Halbritter,Jan Halbritter,Friedhelm Hildebrandt,Friedhelm Hildebrandt,Hans van Bokhoven,Murat Gunel,Joseph G. Gleeson,Joseph G. Gleeson +38 more
TL;DR: Abrogated protein levels and ciliogenesis in affected fibroblasts are shown, suggesting that CSPP1 is involved in neural-specific functions of primary cilia.
Journal ArticleDOI
Clinical Pertinence Metric Enables Hypothesis-Independent Genome-Phenome Analysis for Neurologic Diagnosis
Michael M. Segal,Mostafa Abdellateef,Ayman W. El-Hattab,Brian S Hilbush,Francisco M. De La Vega,Gerard Tromp,Marc S. Williams,Rebecca A. Betensky,Joseph G. Gleeson +8 more
TL;DR: The core conclusion is that automated genome-phenome analysis can be accurate, rapid, and efficient and that an automated process offers a methodology for quality improvement of many components of genomic analysis.