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Ali G. Fenstermaker
Researcher at University of California, San Diego
Publications - 10
Citations - 1326
Ali G. Fenstermaker is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Exome sequencing & Exome. The author has an hindex of 9, co-authored 9 publications receiving 1188 citations. Previous affiliations of Ali G. Fenstermaker include University of Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
Gaia Novarino,Ali G. Fenstermaker,Maha S. Zaki,Matan Hofree,Jennifer L. Silhavy,Andrew Heiberg,Mostafa Abdellateef,Basak Rosti,Eric Scott,Lobna Mansour,Amira Masri,Hülya Kayserili,Jumana Y. Al-Aama,Ghada M H Abdel-Salam,Ariana Karminejad,Majdi Kara,Bülent Kara,Bita Bozorgmehri,Tawfeg Ben-Omran,Faezeh Mojahedi,Iman G. Mahmoud,Naima Bouslam,Ahmed Bouhouche,Ali Benomar,Sylvain Hanein,Laure Raymond,Sylvie Forlani,Massimo Mascaro,Laila Selim,Nabil Shehata,Nasir A. S. Al-Allawi,Parayil Sankaran Bindu,Matloob Azam,Murat Gunel,Ahmet Okay Caglayan,Kaya Bilguvar,Aslıhan Tolun,Mahmoud Y. Issa,Jana Schroth,Emily Spencer,Rasim Ozgur Rosti,Naiara Akizu,Keith K. Vaux,Anide Johansen,Alice A. Koh,Hisham Megahed,Alexandra Durr,Alexis Brice,Giovanni Stevanin,S. Gabriel,Trey Ideker,Joseph G. Gleeson +51 more
TL;DR: Using whole-exome sequencing in combination with network analysis, 18 previously unknown putative HSP genes are identified and validated and link HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease.
Journal ArticleDOI
Exome Sequencing Can Improve Diagnosis and Alter Patient Management
Tracy Dixon-Salazar,Jennifer L. Silhavy,Nitin Udpa,Jana Schroth,Stephanie L. Bielas,Ashleigh E. Schaffer,Jesus Olvera,Vineet Bafna,Maha S. Zaki,Ghada M. H. Abdel-Salam,Lobna Mansour,Laila Selim,Sawsan Abdel-Hadi,Naima Marzouki,Tawfeg Ben-Omran,Nouriya A. Al-Saana,F. Müjgan Sönmez,Figen Celep,Matloob Azam,Kiley J. Hill,Adrienne Collazo,Ali G. Fenstermaker,Gaia Novarino,Naiara Akizu,Kiran V. Garimella,Carrie Sougnez,Carsten Russ,Stacey Gabriel,Joseph G. Gleeson +28 more
TL;DR: Exome sequencing of 118 patients with neurodevelopmental disorders shows that this technique is useful for identifying new pathogenic mutations and for correcting diagnosis in ~10% of cases, and provides proof of principle that genomic strategies are useful in clarifying diagnosis in a proportion of patients with neurological disorders.
Journal ArticleDOI
Wnt/Planar Cell Polarity Signaling Controls the Anterior-Posterior Organization of Monoaminergic Axons in the Brainstem
Ali G. Fenstermaker,Asheeta A. Prasad,Ahmad Bechara,Youri Adolfs,Fadel Tissir,André M. Goffinet,Yimin Zou,R. Jeroen Pasterkamp +7 more
TL;DR: The data suggest that Wnt/planar cell polarity signaling may be a global anterior–posterior guidance mechanism that controls axonal and cellular organization beyond the spinal cord.
Journal ArticleDOI
Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
TL;DR: It is proposed that atypical PKC signaling is required for Wnt-mediated A–P axon guidance and that PI3K can act as a switch to activate Wnt responsiveness during midline crossing.
Journal ArticleDOI
Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis
Wensheng Lin,Yifeng Lin,Jin Li,Jin Li,Ali G. Fenstermaker,Sharon W. Way,Benjamin L.L. Clayton,Stephanie Jamison,Heather P. Harding,David Ron,Brian Popko +10 more
TL;DR: It is found that enhanced activation of PERK signaling specifically in oligodendrocytes significantly attenuated EAE disease severity, which was associated with reduced oligodendedrocyte apoptosis, demyelination, and axonal degeneration.