H
Hitoshi Asakura
Researcher at Niigata University
Publications - 349
Citations - 9450
Hitoshi Asakura is an academic researcher from Niigata University. The author has contributed to research in topics: Ulcerative colitis & Hepatocellular carcinoma. The author has an hindex of 50, co-authored 329 publications receiving 9087 citations. Previous affiliations of Hitoshi Asakura include Keio University & National Institute of Genetics.
Papers
More filters
Journal ArticleDOI
Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease.
Masako Murai,Hiroyuki Yoneyama,Akihisa Harada,Zhang Yi,Christian Vestergaard,Bao-Yu Guo,Kenji Suzuki,Hitoshi Asakura,Kouji Matsushima +8 more
TL;DR: The results suggest that MIP-1alpha-induced migration of CCR5-expressing CD8(+) T cells into the portal areas of the liver plays a significant role in causing liver injury in GVHD; thus, C CR5 and its ligand may be the novel target molecules of therapeutic intervention of hepatic GV HD.
Journal ArticleDOI
Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction.
Masako Murai,Hiroyuki Yoneyama,Hiroyuki Yoneyama,Taichi Ezaki,Makoto Suematsu,Yuya Terashima,Akihisa Harada,Hiromasa Hamada,Hitoshi Asakura,Hiromichi Ishikawa,Kouji Matsushima +10 more
TL;DR: Gut Peyer's patches are required to activate anti-host CTL responses in a well characterized murine acute graft-versus-host reaction (a-GVHR) model, involving transfer of parent lymphocytes into F1 hybrid recipients, and blockade of CTL generation in PPs might offer new strategies for circumventing a-GVHD.
Journal ArticleDOI
Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study.
Takashi Shimoyama,Koji Sawada,Nobuo Hiwatashi,Toshio Sawada,Kei Matsueda,Akihiro Munakata,Hitoshi Asakura,Takao Tanaka,Reiji Kasukawa,Ken Kimura,Yasuo Suzuki,Yukio Nagamachi,Tetsuichiro Muto,Hirokazu Nagawa,Bunei Iizuka,Shozo Baba,Masaru Nasu,Tatsuji Kataoka,Nobuhito Kashiwagi,Abby R. Saniabadi +19 more
TL;DR: Based on the results, it is believed that in patients with active severe UC, patients who are refractory to conventional drugs, granulocyte and monocyte adsorption apheresis is a useful adjunct to conventional therapy.
Journal ArticleDOI
A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma.
Masato Fujii,Yuichiro Shibazaki,Kyoko Wakamatsu,Yutaka Honda,Yusuke Kawauchi,Kenji Suzuki,Somasundaram Arumugam,Kenichi Watanabe,Takafumi Ichida,Hitoshi Asakura,Hiroyuki Yoneyama +10 more
TL;DR: The present study provides the evidence in novel mouse model that NASH-based fibrosis is an essential histological process for diabetic populations to accelerate the development of HCC.
Journal ArticleDOI
Regulation by Chemokines of Circulating Dendritic Cell Precursors, and the Formation of Portal Tract–Associated Lymphoid Tissue, in a Granulomatous Liver Disease
Hiroyuki Yoneyama,Hiroyuki Yoneyama,Kenjiro Matsuno,Yanyun Zhang,Masako Murai,Masako Murai,Meiji Itakura,Sho Ishikawa,Go Hasegawa,Makoto Naito,Hitoshi Asakura,Kouji Matsushima +11 more
TL;DR: Circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines, and Anti-SLC antibody diminished PALT expansion while exacerbating granuloma formation.