H
Hlin Kvartsberg
Researcher at University of Gothenburg
Publications - 35
Citations - 1440
Hlin Kvartsberg is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Neurogranin & Dementia. The author has an hindex of 12, co-authored 28 publications receiving 814 citations. Previous affiliations of Hlin Kvartsberg include Sahlgrenska University Hospital & Karolinska Institutet.
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Journal ArticleDOI
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease
Hlin Kvartsberg,Flora H. Duits,Martin Ingelsson,Niels Andreasen,Annika Öhrfelt,Kerstin Andersson,Gunnar Brinkmalm,Lars Lannfelt,Lennart Minthon,Oskar Hansson,Ulf Andreasson,Charlotte E. Teunissen,Philip Scheltens,Wiesje M. van der Flier,Henrik Zetterberg,Henrik Zetterberg,Erik Portelius,Kaj Blennow +17 more
TL;DR: Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation and may be valuable tools for both early diagnosis and disease stage in Alzheimer's disease.
Journal ArticleDOI
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative.
Thomas K. Karikari,Andrea Lessa Benedet,Nicholas J. Ashton,Juan Lantero Rodriguez,Anniina Snellman,Anniina Snellman,Marc Suárez-Calvet,Paramita Saha-Chaudhuri,Firoza Z. Lussier,Hlin Kvartsberg,Hlin Kvartsberg,Alexis Moscoso Rial,Tharick A. Pascoal,Tharick A. Pascoal,Ulf Andreasson,Ulf Andreasson,Michael Schöll,Michael Schöll,Michael W. Weiner,Pedro Rosa-Neto,Pedro Rosa-Neto,John Q. Trojanowski,Leslie M. Shaw,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Alzheimer’s Disease Neuroimaging Initiative +26 more
TL;DR: This study adds significant weight to the growing body of evidence in the use of plasma p-tau181 as a non-invasive diagnostic and prognostic tool for AD, regardless of clinical stage, which would be of great benefit in clinical practice and a large cost-saving in clinical trial recruitment.
Journal ArticleDOI
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology
Erik Portelius,Erik Portelius,Bob Olsson,Bob Olsson,Kina Höglund,Kina Höglund,Nicholas C. Cullen,Hlin Kvartsberg,Ulf Andreasson,Ulf Andreasson,Henrik Zetterberg,Åsa Sandelius,Leslie M. Shaw,Virginia M.-Y. Lee,David J. Irwin,Murray Grossman,Daniel Weintraub,Daniel Weintraub,Alice Chen-Plotkin,David A. Wolk,Leo McCluskey,Lauren Elman,Jennifer D. McBride,Jon B. Toledo,Jon B. Toledo,John Q. Trojanowski,Kaj Blennow,Kaj Blennow +27 more
TL;DR: It is shown that Ng significantly increased the discrimination between AD and several other disorders, and that high CSF Ng concentrations likely reflect synaptic dysfunction and thatCSF Ng is associated with β-amyloid plaque pathology.
Journal ArticleDOI
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
Konstantin Hellwig,Hlin Kvartsberg,Erik Portelius,Ulf Andreasson,Timo Jan Oberstein,Piotr Lewczuk,Piotr Lewczuk,Kaj Blennow,Johannes Kornhuber,Juan Manuel Maler,Henrik Zetterberg,Henrik Zetterberg,Philipp Spitzer +12 more
TL;DR: Neurogranin and YKL-40 are promising AD biomarkers, independent of and complementary to the established core AD biomarker, reflecting additional pathological changes in the course of AD.
Journal ArticleDOI
Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls
Hlin Kvartsberg,Hlin Kvartsberg,Erik Portelius,Ulf Andreasson,Gunnar Brinkmalm,Konstantin Hellwig,Natalia Lelental,Johannes Kornhuber,Oskar Hansson,Lennart Minthon,Philipp Spitzer,Juan Manuel Maler,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Piotr Lewczuk +15 more
TL;DR: The results suggest that CSF Ng, in particular Ng48–76, might reflect the neurodegenerative processes within the brain, indicating a role for Ng as a potential novel clinical biomarker for synaptic function in AD.