Lauren Elman

TL;DR: Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia and Charcot-Marie-Tooth type 2.

TL;DR: The data imply that increased age and APOE ɛ4 status are risk factors for co-pathologies independent of neurodegenerative disease; that neurodegenersative disease severity influences co- Pathology as evidenced by the prevalence of co- pathology in high Alzheimer's disease and neocortical Lewy body disease, but not intermediate Alzheimer’s disease or limbic LewyBody disease.

TL;DR: It is suggested that inadequate normalization with low-dimensional approaches can result in insufficient removal of shape differences which in turn can confound FA differences in a complex manner, and that utilizing high-dimensional normalization can both significantly minimize the confounding effect of shape Differences to FA differences and provide a more complete description of WM differences.

TL;DR: Findings indicate that tracking poly(GP) proteins in CSF could provide a means to assess target engagement of G4C2 RNA–based therapies in symptomatic C9ORF72 repeat expansion carriers and presymptomatic individuals who are expected to benefit from early therapeutic intervention.

TL;DR: Four plasma analytes were consistently associated with the diagnosis of very mild dementia/MCI/AD in 3 independent clinical cohorts, and these plasma biomarkers may predict underlying AD through their association with CSF AD biomarkers.