H
Hoi-Sang U
Researcher at University of California, San Diego
Publications - 4
Citations - 268
Hoi-Sang U is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Nerve growth factor & Somatic cell. The author has an hindex of 3, co-authored 4 publications receiving 241 citations.
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Journal ArticleDOI
Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease
Mark H. Tuszynski,Mark H. Tuszynski,Jennifer H. Yang,David Barba,Hoi-Sang U,Roy A.E. Bakay,Mary Pay,Eliezer Masliah,James M. Conner,Peter Kobalka,Subhojit Roy,Alan H. Nagahara +11 more
TL;DR: Findings indicate that neurons of the degenerating brain retain the ability to respond to growth factors with axonal sprouting, cell hypertrophy, and activation of functional markers, and growth factor therapy appears safe over extended periods and merits continued testing as a means of treating neurodegenerative disorders.
Journal ArticleDOI
Somatic gene transfer to the adult primate central nervous system:in vitroandin vivocharacterization of cells genetically modified to secrete nerve growth factor
Mark H. Tuszynski,Mark H. Tuszynski,Marie-Claude Senut,Marie-Claude Senut,Jasodhara Ray,Jeffrey A. Roberts,Hoi-Sang U,Fred H. Gage +7 more
TL;DR: Findings indicate that both human and primate fibroblasts can be transduced to produce and secrete NGF, can maintain this production whether in a growing or quiescent state and can elicit robust sprouting responses when pr primates are grafted to the adult brain.
Journal ArticleDOI
Nerve growth factor gene therapy for Alzheimer's disease.
Mark H. Tuszynski,Leon J. Thal,Hoi-Sang U,Mary Pay,Armin Blesch,James M. Conner,H. Lee Vahlsing +6 more
TL;DR: This is a Phase I clinical trial to be conducted in 8 people with early Alzheimer’s disease, with a diagnosis of probable AD, and subjects are evaluated every 2 wk to 3 mo for safety and cognitive function is measured.