Hong Fei

TL;DR: Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans, suggesting differences in its secretion rate from fat.

TL;DR: Northern blots, RNase protection assays, and PCR indicate that Ob-Rb is expressed at a relatively high level in hypothalamus and low level in several other tissues, whereas Ob-Ra is expressed ubiquitously, whereas ob-Rc, -Rd, and -Re RNAs are only detectable using PCR.

TL;DR: In db/db and lesioned mice, quantitative differences in expression level of ob RNA correlated with adipocyte lipid content, suggesting that both the db gene and the hypothalamus are downstream of the ob gene in the pathway that regulates adipose tissue mass.

TL;DR: It is shown that male G PR7-/- mice develop an adult-onset obese phenotype that progressively worsens with age and was greatly exacerbated when animals are fed a high-fat diet, suggesting a potential role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptic W, in regulating energy homeostasis independent of leptin and melanocortin signaling in a sexually dimorphic manner.

TL;DR: This article showed that Fz2 receptor cleavage via the γ-secretase complex is required for postsynaptic development and maturation in Drosophila neuromuscular synapses.