Y
Yiying Zhang
Researcher at Columbia University
Publications - 54
Citations - 18093
Yiying Zhang is an academic researcher from Columbia University. The author has contributed to research in topics: Adipose tissue & Leptin. The author has an hindex of 26, co-authored 47 publications receiving 17218 citations. Previous affiliations of Yiying Zhang include Rockefeller University & University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
Streamson C. Chua,Wendy K. Chung,X. Sharon Wu-Peng,Yiying Zhang,Shun Mei Liu,Louis A. Tartaglia,Rudolph L. Leibel +6 more
TL;DR: The cloning of ob, and the demonstration that it encodes a secreted protein that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis.
Journal ArticleDOI
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
Li Qiang,Liheng Wang,Ning Kon,Wenhui Zhao,Sangkyu Lee,Yiying Zhang,Michael Rosenbaum,Yingming Zhao,Wei Gu,Stephen R. Farmer,Domenico Accili +10 more
TL;DR: It is proposed that SirT1-dependent P parγ deacetylation is a form of selective Pparγ modulation of potential therapeutic import in order to staunch the current obesity epidemic.
Journal ArticleDOI
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
TL;DR: Increases in dietary leucine intake substantially decrease diet-induced obesity, hyperglycemia, and hypercholesterolemia in mice with ad libitum consumption of HFD likely via multiple mechanisms.
Journal ArticleDOI
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.
Margherita Maffei,Hong Fei,Gwo-Hwa Lee,Christian Dani,Pascale Leroy,Yiying Zhang,Richardo Proenca,Raymond Negrel,Gérard Ailhaud,Jeffrey M. Friedman +9 more
TL;DR: In db/db and lesioned mice, quantitative differences in expression level of ob RNA correlated with adipocyte lipid content, suggesting that both the db gene and the hypothalamus are downstream of the ob gene in the pathway that regulates adipose tissue mass.